On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR
文献类型：期刊论文
| 作者 | Chen, Fangyu1,2; Chen, Chao1; Zhao, Dawei1; Zhang, Songping1; Ma, Guanghui1; Su, Zhiguo1; Li, Xiunan1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2020-06-15 |
| 卷号 | 238页码:8 |
| ISSN号 | 0144-8617 |
| 关键词 | Temperature sensitivity Chitosan Hydrogel Sol-gel LF-NMR Temperature control |
| DOI | 10.1016/j.carbpol.2020.116196 |
| 英文摘要 | A temperature controlled low field nuclear magnetic resonance (LF-NMR) T-2 relaxometry technique based on the mobility changes of water trapped in hydrogels, was successfully used for on-line determination of the sol-gel transition temperature for chitosan/beta-glycerophosphate (CS/GP) hydrogels in real time. The LF-NMR results indicated that the gelation temperature decreased gradually with increasing GP concentration, and the results were supported by both thermogravimetric differential scanning calorimetry (DSC) and rheological findings; however, LF-NMR allows non-destructive monitoring of samples during continuous heating. Moreover, as the mobility of water molecules varies greatly during the sol-gel phase transition, the LF-NMR measurement was more sensitive and accurate (RSD <= 0.1 %, n = 5) compared with DSC (RSD: 1.2 %-3.7 %, n = 5) and rheology (RSD: 1.1 %-2.3 %, n = 5). |
| WOS关键词 | KAPPA-CARRAGEENAN ; WATER MOBILITY ; RHEOLOGICAL PROPERTIES ; SUSTAINED DELIVERY ; THERMAL-STABILITY ; DRUG-DELIVERY ; IN-VITRO ; GELATION ; RELEASE ; RELAXATION |
| 资助项目 | National Natural Sciences Foundation of China[21821005] ; National Natural Sciences Foundation of China[21376248] ; National Natural Sciences Foundation of China[21506228] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000526413700022 |
| 资助机构 | National Natural Sciences Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/40002]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Su, Zhiguo; Li, Xiunan |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fangyu,Chen, Chao,Zhao, Dawei,et al. On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR[J]. CARBOHYDRATE POLYMERS,2020,238:8. |
| APA | Chen, Fangyu.,Chen, Chao.,Zhao, Dawei.,Zhang, Songping.,Ma, Guanghui.,...&Li, Xiunan.(2020).On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR.CARBOHYDRATE POLYMERS,238,8. |
| MLA | Chen, Fangyu,et al."On-line monitoring of the sol-gel transition temperature of thermosensitive chitosan/beta-glycerophosphate hydrogels by low field NMR".CARBOHYDRATE POLYMERS 238(2020):8. |
入库方式： OAI收割
来源：过程工程研究所
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