中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen

文献类型：期刊论文

作者Zhang, Yongqiang1,2; Cao, Yingying1,2; Meng, Xiangzhan2; Li, Chunshan1,2; Wang, Hui1,2; Zhang, Suojiang1,2
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
出版日期2020-05-01
卷号189页码:8
关键词Artemisinin Microemulsion Ionic liquid Lid center dot Ibu Transdermal delivery
ISSN号0927-7765
DOI10.1016/j.colsurfb.2020.110886
英文摘要A microemulsion system based on ionic liquid (IL) and deep eutectic compound was proposed to improve the transdermal delivery of artemisinin. Deep eutectic lidocaine ibuprofen (Lid center dot Ibu) was selected as the oil phase, and the imidazolium ionic liquid, 1-hydroxyethyl-3-methylimidazolium chloride ([HOEmim]Cl), was incorporated into the aqueous phase as a transdermal enhancer. The ingredients for the microemulsion in this study were selected, and their ratios were optimized. The optimal microemulsion carrier was composed of 45 wt % of water phase, 45 wt% surfactant phase (containing Tween-80, Span-20, and ethanol (co-surfactant) with the weight ratio of 1:1:1), and 10 wt% Lid center dot Ibu as the oil phase with artemisinin loading of 1.0 wt% (all the ratios were based on the total weight of microemulsion). Physical properties of this microemulsion, including particle size (41.95 +/- 0.85 nm), viscosity (26.65 +/- 0.13 mPa center dot s) and density (1.02 g/cm(3)), were measured. In-vitro transdermal assay showed a remarkable enhancement of artemisinin transport through the skin, with the permeation flux being 3-fold of the value for isopropyl myristate system in 6 h. The impact of IL-based microemulsion (ILME) on stratum corneum (SC) was investigated by DSC, ATR-FTIR and AFM, which unveiled that the ILME possesses the ability of reducing the SC barrier by disrupting the regular arrangement of keratin, resulting in enhancement of transdermal delivery of artemisinin. This current work suggested that the microemulsion proposed here had an excellent capability to promote the transdermal delivery of artemisinin, which might also be a promising vehicle for the skin delivery of other hydrophobic natural drugs.
WOS关键词ANTIMALARIAL-DRUG ; IN-VITRO ; PERMEATION ; SKIN ; EXTRACTION ; BIOAVAILABILITY ; CYCLODEXTRIN ; FORMULATION ; SYSTEM ; MEDIA
资助项目Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM-2019A12] ; CAS Pioneer Hundred Talents Program, National Natural Science Foundation of China[21878311] ; Major Program of National Natural Science Foundation of China[21890762] ; K. C. Wong Education Foundation[GJTD-2018-04]
WOS研究方向Biophysics ; Chemistry ; Materials Science
语种英语
WOS记录号WOS:000527314700053
出版者ELSEVIER
资助机构Innovation Academy for Green Manufacture, Chinese Academy of Sciences ; CAS Pioneer Hundred Talents Program, National Natural Science Foundation of China ; Major Program of National Natural Science Foundation of China ; K. C. Wong Education Foundation
源URL[http://ir.ipe.ac.cn/handle/122111/40334]  
专题中国科学院过程工程研究所
通讯作者Wang, Hui; Zhang, Suojiang
作者单位1.Univ Chinese Acad Sci, Sino Danish Coll, Yanqihu Campus,380 Huaibeizhuang, Beijing 101408, Peoples R China
2.Chinese Acad Sci, Innovat Acad Green Manufacture, CAS Key Lab Green Proc & Engn,Beijing Key Lab Ion, State Key Lab Multiphase Complex Syst,Inst Proc E, 1 Beierjie, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yongqiang,Cao, Yingying,Meng, Xiangzhan,et al. Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,189:8.
APA Zhang, Yongqiang,Cao, Yingying,Meng, Xiangzhan,Li, Chunshan,Wang, Hui,&Zhang, Suojiang.(2020).Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen.COLLOIDS AND SURFACES B-BIOINTERFACES,189,8.
MLA Zhang, Yongqiang,et al."Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen".COLLOIDS AND SURFACES B-BIOINTERFACES 189(2020):8.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。