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Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification

文献类型：期刊论文

作者Na, Xiangming3; Guo, Jianjun2; Li, Tong2; Zhou, Weiqing1,3; Ma, Guanghui3
刊名CHEMNANOMAT
出版日期2020-04-29
页码5
关键词Double emulsion Membrane emulsification Single-core microcapsule Controllable structures
ISSN号2199-692X
DOI10.1002/cnma.202000175
英文摘要A scalable and versatile strategy was developed for fabrication of double emulsion-templated single-core PLGA microcapsules with narrow size distribution and controllable structure. A single-core water-in-oil-in-water (W-1/O/W-2) double emulsion was generated from two-step premix membrane emulsification, which guaranteed the narrow size distribution and size controllability of emulsion. During a secondary emulsification process, coalescence of W-1 droplets within oil droplet allowed multi-core W-1/O/W-2 double emulsion to spontaneously transform to a single-core one. The osmotic pressure and solvent diffusion rate were used to control the shell-thickness and surface morphology of single-core PLGA microcapsules, respectively. The method proposed in this study could be extended for the fabrication of uniform single-core polymeric microcapsules with controllable structures and size.
资助项目National Natural Science Foundation of China[21902160] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020405] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000529198200001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/40393]  
专题中国科学院过程工程研究所
通讯作者Zhou, Weiqing; Ma, Guanghui
作者单位1.Chinese Acad Sci, Inst Stem Cell & Regenerat, 1 North 2nd St, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Na, Xiangming,Guo, Jianjun,Li, Tong,et al. Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification[J]. CHEMNANOMAT,2020:5.
APA Na, Xiangming,Guo, Jianjun,Li, Tong,Zhou, Weiqing,&Ma, Guanghui.(2020).Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification.CHEMNANOMAT,5.
MLA Na, Xiangming,et al."Double Emulsion-Templated Single-Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification".CHEMNANOMAT (2020):5.

入库方式： OAI收割

来源：过程工程研究所

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