A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis
文献类型:期刊论文
作者 | Wu, Guanghao3; Wei, Wei2; Zhang, Jinfeng3; Nie, Weidong3; Yuan, Lan1; Huang, Yuanyu3; Zuo, Liping3; Huang, Lili3; Xi, Xiaobo2; Xie, Hai-Yan3 |
刊名 | BIOMATERIALS |
出版日期 | 2020-08-01 |
卷号 | 250页码:13 |
ISSN号 | 0142-9612 |
关键词 | Self-driven Bioinspired Leukocyte Membranes Inflammation-chemotaxis Atherosclerosis |
DOI | 10.1016/j.biomaterials.2020.119963 |
英文摘要 | Atherosclerosis, as a silent killer, remains one of the most common causes of human morbidity and mortality worldwide due to the lack of efficient strategy for early detection and targeted therapy. In this work, a self-driven bioinspired nanovehicle is developed, which can accurately manage early atherosclerosis with simultaneously multiple-targeting, dual-modality therapy as well as noninvasive magnetic resonance imaging (MRI). The magnetic nanoclusters (MNCs) with satisfactory superparamagnetism are camouflaged with leukocyte membranes, thus acquiring inherently targeting and transmigrating capabilities to intimal foam cells in early atherosclerotic lesions, which is validated using tailor-made microfluidic devices and transwell assays. Upon sequentially embedding an anti-inflammatory drug simvastatin (ST) and decorating a targetable apolipoprotein A-I mimetic 4F peptide (AP), the as-fabricated MNC@M-ST/AP exhibits excellent anti-atherosclerotic effects by alleviating inflammation and oxidative stress as well as promoting cholesterol efflux via RCT pathways. This bioinspired leukocyte membrane-hitchhiking strategy will open new perspectives for the future clinical translations of biocompatible nanosystem in early detection and treatment of atherosclerosis. |
WOS关键词 | Density-lipoproteins ; Pathogenesis ; Macrophages ; Nanoparticles ; Nanomedicine ; Magnetosomes ; Cells |
资助项目 | National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001] |
WOS研究方向 | Engineering ; Materials Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000530752200001 |
资助机构 | National Natural Science Foundation of China ; National Science and Technology Major Project |
源URL | [http://ir.ipe.ac.cn/handle/122111/40435] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Xie, Hai-Yan |
作者单位 | 1.Peking Univ, Med & Hlth Anal Ctr, Xueyuan Rd, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 3.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Guanghao,Wei, Wei,Zhang, Jinfeng,et al. A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis[J]. BIOMATERIALS,2020,250:13. |
APA | Wu, Guanghao.,Wei, Wei.,Zhang, Jinfeng.,Nie, Weidong.,Yuan, Lan.,...&Xie, Hai-Yan.(2020).A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis.BIOMATERIALS,250,13. |
MLA | Wu, Guanghao,et al."A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis".BIOMATERIALS 250(2020):13. |
入库方式: OAI收割
来源:过程工程研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。