Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery
文献类型：期刊论文
| 作者 | Zhou, Mengyun2; Xing, Yi2; Li, Weike2; Li, Xiaoyu1; Zhang, Xueji2; Du, Xin2 |
| 刊名 | MICROPOROUS AND MESOPOROUS MATERIALS
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 302页码:10 |
| 关键词 | Mesoporous organosilica Thioether-bridged framework Nanocapsules Charge reversal Drug delivery |
| ISSN号 | 1387-1811 |
| DOI | 10.1016/j.micromeso.2020.110242 |
| 英文摘要 | The drug delivery nanosystems with weak acid-triggered surface charge reversal function should be promising for efficient chemotherapy due to the prolonged blood circulation and enhanced the cellular uptake. However, there are only limited reports up to now. In this study, we fabricated a hybrid nanocapsule with a negative-to-positive charge-reversal outer layer triggered by the weak acidity in tumor microenvironment. The short branched polyethylenimine (PEI) with positive charge and weak acid-sensitive hexahydmphthalic anhydride with negative charge were successively modified on the surface of small uniform thioether-bridged hollow mesoporous silica nanospheres with multiple cavities. The modification of PEI as a linker was more favorable for charge reversal than that of aminopropyl group. The constructed hybrid nanocapsules exhibited weak acid (pH 6.0)-triggered charge reversal and drug release behaviors, thus effectively inhibiting the growth of A549 cancer cells. The surface functionalization of hybrid nanocapsules opens new opportunities for the development of silica-based hybrid nanosystems for promising drug delivery. |
| WOS关键词 | SILICA NANOPARTICLES ; SILSESQUIOXANE FRAMEWORK ; CONTROLLED-RELEASE ; EFFICIENT ; NANOHYBRIDS |
| 资助项目 | Fundamental Research Funds for the Central Universities[FRF-TP-19-017B1] ; National Natural Science Foundation of China[21501009] ; National Natural Science Foundation of China[51671181] ; Beijing Municipal Science and Technology Commission[z131102002813058] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000532052100046 |
| 出版者 | ELSEVIER |
| 资助机构 | Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/40467]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Li, Xiaoyu; Zhang, Xueji; Du, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydromet Cleaner Prod Technol, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Dept Chem & Biol Engn, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Mengyun,Xing, Yi,Li, Weike,et al. Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2020,302:10. |
| APA | Zhou, Mengyun,Xing, Yi,Li, Weike,Li, Xiaoyu,Zhang, Xueji,&Du, Xin.(2020).Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery.MICROPOROUS AND MESOPOROUS MATERIALS,302,10. |
| MLA | Zhou, Mengyun,et al."Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery".MICROPOROUS AND MESOPOROUS MATERIALS 302(2020):10. |
入库方式： OAI收割
来源：过程工程研究所
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