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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry

文献类型：期刊论文

作者Lu, Guihong2; Zuo, Liping2; Zhang, Jinfeng2; Zhu, Houshun2; Zhuang, Wanru2; Wei, Wei1; Xie, Hai-Yan2
刊名BIOMATERIALS SCIENCE
出版日期2020-04-21
卷号8期号:8页码:2283-2288
ISSN号2047-4830
DOI10.1039/d0bm00088d
英文摘要Highly efficient tumor-targeted therapy remains a great challenge due to the complexity and heterogeneity of tumor tissues. Herein, we developed an in vivo two-step tumor-targeting strategy by combining metabolic lipid-engineering with a stain-promoted azide-alkyne 1,3-dipolar cycloaddition (SPAAC) reaction, independent of the tumor microenvironment and cell phenotype. Firstly, exogenously-supplied azidoethyl-cholines (AECho) were metabolically incorporated into the cell membranes in tumor tissues through the intrinsic biosynthesis of phosphatidylcholine. The pre-inserted and accumulated azido groups (N-3) could subsequently serve as 'artificial chemical receptors' for the specific anchoring of dibenzocyclooctyne (DBCO) modified biomimetic nanoparticles (DBCO-RBCG@ICG) via in situ click chemistry, resulting in significantly enhanced tumor-targeting and then an improved photothermal therapy effect. Such a two-step targeting strategy based on these cutting-edge techniques provided new insights into the universal and precise functionalization of living tissues for site-specific drug delivery in the diagnosis and treatment of various diseases.
WOS关键词VIVO ; PHOSPHOLIPIDS ; HETEROGENEITY ; NANOPARTICLES ; MAGNETOSOMES ; PROTEINS ; DELIVERY ; BIOLOGY ; CELLS
资助项目National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Science and Technology Major Project[2018ZX 10301405-001]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000530471400017
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; National Science and Technology Major Project
源URL[http://ir.ipe.ac.cn/handle/122111/40489]  
专题中国科学院过程工程研究所
通讯作者Xie, Hai-Yan
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
2.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Guihong,Zuo, Liping,Zhang, Jinfeng,et al. Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry[J]. BIOMATERIALS SCIENCE,2020,8(8):2283-2288.
APA Lu, Guihong.,Zuo, Liping.,Zhang, Jinfeng.,Zhu, Houshun.,Zhuang, Wanru.,...&Xie, Hai-Yan.(2020).Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry.BIOMATERIALS SCIENCE,8(8),2283-2288.
MLA Lu, Guihong,et al."Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry".BIOMATERIALS SCIENCE 8.8(2020):2283-2288.

入库方式： OAI收割

来源：过程工程研究所

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