Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences
文献类型：期刊论文
| 作者 | Ren, Peng1,2; Li, Jingtao3; Zhao, Luyang2; Wang, Anhe2; Wang, Meiyue2; Li, Jieling2; Jian, Honglei2; Li, Xiaoou3; Yan, Xuehai2; Bai, Shuo1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-05-13 |
| 卷号 | 12期号:19页码:21433-21440 |
| 关键词 | dipeptide self-assembly shear-thinning hydrogel self-healing endoscopic submucosal dissection |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.0c03038 |
| 英文摘要 | Dipeptide self-assembled hydrogels have potential biomedical applications because of their great biocompatibility, bioactivity, and tunable physicochemical properties, which can be modulated in the molecular level by design of amino acid sequences. Herein, a series of dipeptides (Fmoc-FL, -YL, -LL, and -YA) are designed to form shear-thinning hydrogels with self-healing and tunable mechanical properties by adjusting the synergetic effect of hydrophobic interactions (p-p stacking and hydrophobic effect) and hydrogen bonds of peptides through substitution of amino acid residues. The enhancement of hydrophobic interactions is a primary factor to promote mechanical rigidity of hydrogels, and strong hydrogen-bonding interactions between molecules contribute to the instantaneous self-healing property, which is supported by experimental studies (FTIR, CD, SEM, AFM, and rheology) and molecular dynamics simulations. The injectable dipeptide hydrogels were certified as an ideal endoscopic submucosal dissection filler to make operation convenient and secure in mice and living mini-pig's experiments with a longer duration time, higher stiffness, and lower inflammatory response than commercial clinical fillers. |
| WOS关键词 | BETA-SHEET ; DESIGN ; FABRICATION ; TRANSITION ; GELATION |
| 资助项目 | National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; China-Japan Friendship Hospital Research funding[2016-1-MS-5] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2019KF-02] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000535246100026 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; China-Japan Friendship Hospital Research funding ; Open Funding Project of the State Key Laboratory of Biochemical Engineering |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/40851]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Li, Jingtao; Bai, Shuo |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Peng,Li, Jingtao,Zhao, Luyang,et al. Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(19):21433-21440. |
| APA | Ren, Peng.,Li, Jingtao.,Zhao, Luyang.,Wang, Anhe.,Wang, Meiyue.,...&Bai, Shuo.(2020).Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences.ACS APPLIED MATERIALS & INTERFACES,12(19),21433-21440. |
| MLA | Ren, Peng,et al."Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences".ACS APPLIED MATERIALS & INTERFACES 12.19(2020):21433-21440. |
入库方式： OAI收割
来源：过程工程研究所
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