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Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

文献类型：期刊论文

作者Xi, Xiaobo1; Ye, Tong1,2; Wang, Shuang2; Na, Xiangming2; Wang, Jianghua1,2; Qing, Shuang1,2; Gao, Xiaoyong2; Wang, Changlong1,2; Li, Feng1,2; Wei, Wei1,2
刊名SCIENCE ADVANCES
出版日期2020-05-01
卷号6期号:21页码:16
ISSN号2375-2548
DOI10.1126/sciadv.aay7735
英文摘要Therapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-based formulation for high-performance cancer vaccinations. The special self-healing feature provides a mild and efficient paradigm for antigen microencapsulation. After vaccination, these microcapsules create a favorable immunization microenvironment in situ, wherein antigen release kinetics, recruited cell behavior, and acid surrounding work in a synergetic manner. In this case, we can effectively increase the antigen utilization, improve the antigen presentation, and activate antigen presenting cells. As a result, effective T cell response, potent tumor inhibition, antimetastatic effects, and prevention of postsurgical recurrence are achieved with various types of antigens, while neoantigen was encapsuled and evaluated in different tumor models.
WOS关键词SYNTHETIC VACCINES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; DELIVERY ; IMMUNOTHERAPY ; ANTIGENS ; MICROENCAPSULATION ; NANOPARTICLES ; ENCAPSULATION ; ADJUVANTS
资助项目National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000537235300007
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China
源URL[http://ir.ipe.ac.cn/handle/122111/40980]  
专题中国科学院过程工程研究所
通讯作者Wei, Wei; Ma, Guanghui
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Xi, Xiaobo,Ye, Tong,Wang, Shuang,et al. Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination[J]. SCIENCE ADVANCES,2020,6(21):16.
APA Xi, Xiaobo.,Ye, Tong.,Wang, Shuang.,Na, Xiangming.,Wang, Jianghua.,...&Ma, Guanghui.(2020).Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination.SCIENCE ADVANCES,6(21),16.
MLA Xi, Xiaobo,et al."Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination".SCIENCE ADVANCES 6.21(2020):16.

入库方式： OAI收割

来源：过程工程研究所

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