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Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

文献类型：期刊论文

作者Mao, Jingxin5,6; Zhang, Qinghai4,6; Zhang, Haiyan3; Zheng, Ke2; Wang, Rui1; Wang, Guoze4,6
刊名FRONTIERS IN ENDOCRINOLOGY
出版日期2020-05-15
卷号11页码:12
关键词papillary thyroid carcinoma (PTC) lymph node metastasis (LNM) risk factor prognostic factor meta-analysis
ISSN号1664-2392
DOI10.3389/fendo.2020.00265
英文摘要Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p <0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p <0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p <0.0001); tumor size >= 1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p <0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p <0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.
WOS关键词FINE-NEEDLE-ASPIRATION ; PREDICTIVE FACTORS ; EXTRATHYROIDAL EXTENSION ; TUMOR MULTIFOCALITY ; CANCER ; MICROCARCINOMA ; RECURRENCE ; IMPACT ; SURVEILLANCE ; DISSECTION
资助项目first-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine[2017 [85]] ; Science and Technology Support Program Project of Guizhou Province, China[2044] ; Science and Technology Support Program Project of Guizhou Province, China[2860] ; Science and Technology Support Program Project of Guizhou Province, China[2349]
WOS研究方向Endocrinology & Metabolism
语种英语
WOS记录号WOS:000538534800001
出版者FRONTIERS MEDIA SA
资助机构first-class discipline construction project in Guizhou Province-Public Health and Preventive Medicine ; Science and Technology Support Program Project of Guizhou Province, China
源URL[http://ir.idsse.ac.cn/handle/183446/7701]  
专题深海科学研究部_深海极端环境模拟研究实验室
通讯作者Wang, Guoze
作者单位1.Guilin Med Univ, Coll Pharm, Dept Pharmacol, Guilin, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, Chongqing, Peoples R China
3.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya, Peoples R China
4.Guizhou Med Univ, Coll Food Sci, Guiyang, Peoples R China
5.Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China
6.Guizhou Med Univ, Minist Educ, Key Lab Environm Pollut Monitoring & Dis Control, Sch Publ Hlth, Guiyang, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,et al. Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ENDOCRINOLOGY,2020,11:12.
APA Mao, Jingxin,Zhang, Qinghai,Zhang, Haiyan,Zheng, Ke,Wang, Rui,&Wang, Guoze.(2020).Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.FRONTIERS IN ENDOCRINOLOGY,11,12.
MLA Mao, Jingxin,et al."Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis".FRONTIERS IN ENDOCRINOLOGY 11(2020):12.

入库方式： OAI收割

来源：深海科学与工程研究所

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