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Development and application of magnetic solid phase extraction in tandem with liquid-liquid extraction method for determination of four tetracyclines by HPLC with UV detection

文献类型：期刊论文

作者Tang, Hong-zhi1,2; Wang, Yong-hui2; Li, Shuang2; Wu, Jin2; Gao, Zhi-xian2; Zhou, Huan-ying2
刊名JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
出版日期2020-03-20
页码10
关键词Tetracyclines Magnetic solid phase extraction Liquid-liquid extraction Amino functionalized magnetite nanoparticle HPLC
ISSN号0022-1155
DOI10.1007/s13197-020-04320-w
英文摘要A novel HPLC-UV method was developed for the determination of four tetracyclines based on magnetic solid phase extraction in tandem with liquid-liquid extraction. The water-soluble amino functionalized magnetite nanoparticle (MNP-NH2) was used as an adsorbent for extraction/preconcentration of tetracycline, oxytetracycline, chlortetracycline, and doxycycline from bovine milk samples. Fourier transform infrared spectrometer, transmission electron microscope, X-ray diffraction, and elemental analyze techniques were used to characterize the material. Some key parameters which influence liquid-liquid extraction and magnetic dispersive solid-phase extraction procedure, including volume of extraction solvent, the amount of adsorbent, the pH, extraction and desorption time, the composition of the eluent, and elution frequency were investigated. The proposed method exhibited a linear range of 50.0-2500.0 mu g L-1 (r(2) = 0.9941) with and good reproducibility (RSD < 2.2%, n = 3). The limit of detection and quantification were 40.0 and 50.0 mu g L-1. This method was verified using milk sample spiked with four tetracyclines (100.0-200.0 mu g L-1), and accuracies of 87.8-107.5%, which confirmed its applicability in real-sample analysis. The proposed method also shows potential application prospects for other water-soluble adsorbents.
WOS关键词BIOLOGICAL-FLUIDS ; MILK SAMPLES ; OXYTETRACYCLINE ; CHROMATOGRAPHY ; NANOPARTICLES ; ANTIBIOTICS ; DEGRADATION ; DOXYCYCLINE ; SEPARATION ; COMPLEXES
资助项目National Key R&D Program of China[2017YFC1601101] ; Tianjin Scientific and Technology Support ProgramFunding Agency[16YFZCNC00730]
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:000520904200003
出版者SPRINGER INDIA
资助机构National Key R&D Program of China ; Tianjin Scientific and Technology Support ProgramFunding Agency
源URL[http://ir.idsse.ac.cn/handle/183446/7527]  
专题研究生部
通讯作者Gao, Zhi-xian; Zhou, Huan-ying
作者单位1.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Lab Deep Sea Microbial Cell Biol, Sanya, Peoples R China
2.Tianjin Inst Environm & Operat Med, Tianjin Key Lab Risk Assessment & Control Technol, 1 DaLi Rd, Tianjin 300050, Peoples R China
推荐引用方式
GB/T 7714		 Tang, Hong-zhi,Wang, Yong-hui,Li, Shuang,et al. Development and application of magnetic solid phase extraction in tandem with liquid-liquid extraction method for determination of four tetracyclines by HPLC with UV detection[J]. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,2020:10.
APA Tang, Hong-zhi,Wang, Yong-hui,Li, Shuang,Wu, Jin,Gao, Zhi-xian,&Zhou, Huan-ying.(2020).Development and application of magnetic solid phase extraction in tandem with liquid-liquid extraction method for determination of four tetracyclines by HPLC with UV detection.JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,10.
MLA Tang, Hong-zhi,et al."Development and application of magnetic solid phase extraction in tandem with liquid-liquid extraction method for determination of four tetracyclines by HPLC with UV detection".JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2020):10.

入库方式： OAI收割

来源：深海科学与工程研究所

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