Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
文献类型:期刊论文
作者 | Ma, Xiaoyu; Wang, Lin; Huang, De; Li, Yunyan; Yang, Dongdong; Li, Tingting; Li, Fudong; Sun, Linchong; Wei, Haoran; He, Kun |
刊名 | Nature Communications |
出版日期 | 2017-11-15 |
DOI | 10.1038/s41467-017-01647-5 |
英文摘要 | Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to optimize the growth advantage for cancer cells are still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP). We find that Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By activating G6PD through promoting the formation of its active dimer, Plk1 increases PPP flux and directs |
URL标识 | 查看原文 |
语种 | 英语 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/43276] |
专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
作者单位 | 1.Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of China, Hefei 230027, Ch 2.Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. 3.Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, 100850, China. 4.High Magnetic Field Laboratory, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei, Anhui 230031, China |
推荐引用方式 GB/T 7714 | Ma, Xiaoyu,Wang, Lin,Huang, De,et al. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway[J]. Nature Communications,2017. |
APA | Ma, Xiaoyu.,Wang, Lin.,Huang, De.,Li, Yunyan.,Yang, Dongdong.,...&Zhang, Huafeng.(2017).Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.Nature Communications. |
MLA | Ma, Xiaoyu,et al."Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway".Nature Communications (2017). |
入库方式: OAI收割
来源:合肥物质科学研究院
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