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Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein

文献类型：期刊论文

作者Dong WJ2,3,4; Ye J2,3,4; Zhou JZ2,3,4; Wang WJ2,3,4; Wang HL2,3,4; Zheng X(郑旭)1; Yang YF2,3,4; Xia XJ2,3,4; Liu YL2,3,4
刊名ACTA PHARMACEUTICA SINICA B
出版日期2020-08-01
卷号10期号:8页码:1576-1585
关键词Nanoparticles Inhaled delivery Mucus-penetrative Mucoadhesive Baicalein
ISSN号2211-3835
DOI10.1016/j.apsb.2019.10.002
通讯作者Liu, Yuling(ylliu@imm.ac.cn)
英文摘要Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within the respiratory tract mucus. However, the interaction between nanoparticles and mucus, and how these interactions impact distribution has not been extensively investigated. In this study, polymeric nanoparticles loaded with a baicalein-phospholipid complex were modified with two kinds of polymers, mucoadhesive and mucus-penetrative polymer. Systematic investigations on the physicochemical property, mucus penetration, transepithelial transport, and tissue distribution were performed to evaluate the interaction of nanoparticles with the respiratory tract. Both nanoparticles had a similar particle size and good biocompatibility, exhibited a sustained-release profile, but showed a considerable difference in zeta potential. Interestingly, mucus-penetrative nanoparticles exhibited a higher diffusion rate in mucus, deeper penetration across the mucus layer, enhanced in vitro cellular uptake, increased drug distribution in airways, and superior local distribution and bioavailability as compared to mucoadhesive nanoparticles. These results indicate the potential of mucus-penetrative nanoparticles in design of a rational delivery system to improve the efficiency of inhaled therapy by promoting mucus penetration and increasing local distribution and bioavailability. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
分类号一类
WOS关键词BIODEGRADABLE NANOPARTICLES ; PULMONARY DELIVERY ; PACLITAXEL ; BIOAVAILABILITY ; ABSORPTION ; INHALATION ; THERAPY
资助项目National Science and Technology Major Project of China[2018ZX09721003] ; National Science and Technology Major Project of China[2018ZX09711001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000567649600016
资助机构National Science and Technology Major Project of China
其他责任者Liu, Yuling
源URL[http://dspace.imech.ac.cn/handle/311007/85213]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel For, Beijing 100050, Peoples R China;
3.Peking Union Med Coll, Beijing 100050, Peoples R China;
4.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;
推荐引用方式
GB/T 7714		 Dong WJ,Ye J,Zhou JZ,et al. Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein[J]. ACTA PHARMACEUTICA SINICA B,2020,10(8):1576-1585.
APA Dong WJ.,Ye J.,Zhou JZ.,Wang WJ.,Wang HL.,...&Liu YL.(2020).Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein.ACTA PHARMACEUTICA SINICA B,10(8),1576-1585.
MLA Dong WJ,et al."Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein".ACTA PHARMACEUTICA SINICA B 10.8(2020):1576-1585.

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来源：力学研究所

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