Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents
文献类型：期刊论文
| 作者 | Bai, Wenjing; Ji, Jianxin; Huang, Qiang; Wei, Wei |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 61期号:40 |
| 关键词 | Thiourea derivatives Antitumor Antiangiogenesis RTK inhibitors |
| 英文摘要 | A series of novel thiourea derivatives were synthesized and evaluated by biological activities. Among them, compound 10e containing 3,5-bis(trifluoromethyl)phenyl moiety (R-1) at the terminal thiourea and phenylamino (R-2) at the terminal acyl position showed the best cytotoxic activities against seven cancer cell lines (NCI-H460, Colo-205, HCT116, MDA-MB-231, MCF-7, HepG2, PLC/PRF/5) and HUVECs. Moreover, compound 10e moderately inhibited various RTKs such as VEGFR2, VEGFR3, and PDGFR beta. Notably, 10e exhibited much better inhibitory effect of tumor formation and antiangiogenic activities than Sorafenib and Regorafenib at the same concentration. Further docking studies suggested that 10e could serve as potential candidate for cancer therapy. (C) 2020 Elsevier Ltd. All rights reserved. |
| 源URL | [http://210.75.249.4/handle/363003/60237]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Bai, Wenjing,Ji, Jianxin,Huang, Qiang,et al. Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents[J]. TETRAHEDRON LETTERS,2020,61(40). |
| APA | Bai, Wenjing,Ji, Jianxin,Huang, Qiang,&Wei, Wei.(2020).Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents.TETRAHEDRON LETTERS,61(40). |
| MLA | Bai, Wenjing,et al."Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents".TETRAHEDRON LETTERS 61.40(2020). |
入库方式： OAI收割
来源：西北高原生物研究所
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