Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery
文献类型：期刊论文
| 作者 | Zhang, Hui; Wang, Jianchao; Zeng, Yingzhe; Wang, Guangshuo; Han, Shuai; Yang, Zhitang; Li, Baowei; Wang, Xiaomin; Gao, Jie; Zheng, Liyun |
| 刊名 | PHYSICS LETTERS A
 |
| 出版日期 | 2020 |
| 卷号 | 384期号:24 |
| 关键词 | CoFe2O4 nanoparticles Leucine Controlled synthesis Biocompatibility Drug delivery |
| 英文摘要 | This work was primarily focused on the synthesis, characterization and biomedical applications of cobalt ferrite (CoFe2O4) nanoparticles, which were synthesized by a facile solvothermal method using an amino acid of Leucine (Leu) as the surface coating agents. The morphology, structure and properties of the as-synthesized uncoated and Leu-coated CoFe2O4 nanoparticles were characterized in detail by means of XRD, SEM, TEM, DLS, FTIR, XPS, TGA and SQUID. More importantly, it was found that the Leu-coated CoFe2O4 nanoparticles can be used as the efficient drug delivery with a drug loading capacity of 0.32 mg/mg for doxorubicin hydrochloride (DOX), and the loaded DOX demonstrated a sustained and progressive release manner. The in vitro cytotoxicity studies towards the HeLa cells were carried out, and the results indicated that the Leu-coated CoFe2O4 nanoparticles exhibited a relatively high cell viability compared with that of bare CoFe2O4 nanoparticles and the DOX loaded Leu-coated CoFe2O4 nanoparticles presented an obvious cytotoxic effect on HeLa cells. (C) 2020 Elsevier B.V. All rights reserved. |
| 源URL | [http://210.75.249.4/handle/363003/60348]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Hui,Wang, Jianchao,Zeng, Yingzhe,et al. Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery[J]. PHYSICS LETTERS A,2020,384(24). |
| APA | Zhang, Hui.,Wang, Jianchao.,Zeng, Yingzhe.,Wang, Guangshuo.,Han, Shuai.,...&Yu, Ruitao.(2020).Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery.PHYSICS LETTERS A,384(24). |
| MLA | Zhang, Hui,et al."Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery".PHYSICS LETTERS A 384.24(2020). |
入库方式： OAI收割
来源：西北高原生物研究所
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