Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice
文献类型：期刊论文
| 作者 | Jie, Duo; Gao, Tingting; Shan, Zhongshu; Song, Jiayin; Zhang, Ming; Kurskaya, Olga; Sharshov, Kirill; We, Lixin; Bi, Hongtao |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2020 |
| 卷号 | 146 |
| 关键词 | Ma-Nuo-Xi decoction Polysaccharide lmmunostimulating effect Cyclophosphamide-induced immunosuppression Tibetan medicine |
| 英文摘要 | Ma-Nuo-Xi Decoction (MNXD) is well-known in Tibetan medicine to be in line with the theory of treatment determination based on syndrome differentiation. However, the components responsible for its immunomodulating effect are unknown. In this study, three polysaccharide components-MNXD-P, MNXD-BD-P, and MNXD-AD-P-were isolated from MNXD and its basic and auxiliary prescription decoctions, of which MNXD-BD-P is composed of beta-(1,4)-d-glucan and RG-I pectin, MNXD-AD-P contains mainly alpha-(1,4)-D-glucan and some amount of arabinogalactan and/or arabinorhamnogalactan, and MNXD-P contains components of both MNXD-BD-P and MNXD-AD-P. And treatment with these polysaccharides could significantly improve the host's specific and non-specific immunity, including cellular and humoral immunities, as well as promote recovery from myelosuppression in cyclophosphamide (CTX)-immunosuppressed mice. To our knowledge, this is the first report on chemical and immunoactivity study on polysaccharides from traditional Tibetan medicine compounds, which may provide a new idea for development of carbohydrate drugs from them. (C) 2019 Published by Elsevier B.V. |
| 源URL | [http://210.75.249.4/handle/363003/60393]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Jie, Duo,Gao, Tingting,Shan, Zhongshu,et al. Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,146. |
| APA | Jie, Duo.,Gao, Tingting.,Shan, Zhongshu.,Song, Jiayin.,Zhang, Ming.,...&Bi, Hongtao.(2020).Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,146. |
| MLA | Jie, Duo,et al."Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 146(2020). |
入库方式： OAI收割
来源：西北高原生物研究所
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