Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis
文献类型：期刊论文
| 作者 | He, Zhen; Yan, Rong-Ge; Zhang, Xiao-Na; Yang, Qi-En |
| 刊名 | GENES
 |
| 出版日期 | 2020 |
| 卷号 | 11期号:1 |
| 关键词 | Rybp spermatogenesis meiosis germ cells polycomb group 1 |
| 英文摘要 | Spermatogenesis is a complex cellular-differentiation process that relies on the precise regulation of gene expression in spermatogonia, meiotic, and postmeiotic germ cells. The Ring 1 and YY1 binding protein (Rybp) is a member of the mammalian polycomb-group (PcG) protein family that plays multifunctional roles in development. Previous findings indicate that Rybp may function as an important regulator of meiosis. However, its expression in the testes and function in spermatogenesis have not been examined. In this study, we investigated Rybp expression in postnatal mouse testes using qRT-PCR and immunohistochemistry. We also examined the function of Rybp in spermatogenesis by using a conditional-knockout approach. Results showed that the relative expression of Rybp mRNA was significantly upregulated in the testes of postnatal day (PD) 6 mice. Immunofluorescent staining revealed that Rybp was enriched in the spermatocytes. Surprisingly, a conditional deletion of Rybp in fetal germ cells did not affect the fertility or normal development of spermatogenic cells. Further analysis revealed that Rybp deletion resulted in a decreased expression of meiosis-related genes, but that meiosis progression was normal. Together, these findings suggest that Rybp expression was enriched in spermatocytes, but that it was not required for spermatogenesis. |
| 源URL | [http://210.75.249.4/handle/363003/60465]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | He, Zhen,Yan, Rong-Ge,Zhang, Xiao-Na,et al. Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis[J]. GENES,2020,11(1). |
| APA | He, Zhen,Yan, Rong-Ge,Zhang, Xiao-Na,&Yang, Qi-En.(2020).Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.GENES,11(1). |
| MLA | He, Zhen,et al."Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis".GENES 11.1(2020). |
入库方式： OAI收割
来源：西北高原生物研究所
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