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Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients

文献类型：期刊论文

作者Huo,Xingxing1,2,3,4; Qi,Jian1,2,3; Huang,Kaiquan4; Bu,Su4; Yao,Wei4; Chen,Ying4; Nie,Jinfu1,2,3
刊名BMC Cancer
出版日期2020-08-17
卷号20
关键词Autophagy HCC Autophagy-related genes Molecular signature Drug sensitivity
DOI10.1186/s12885-020-07277-3
通讯作者Nie,Jinfu(jeffnie@cmpt.ac.cn)
英文摘要AbstractBackgroundAutophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been proposed to play a pivotal role in the progression of hepatocellular carcinoma (HCC).MethodsUnivariate Cox regression analysis of overall survival (OS) was performed to identify risk-associated autophagy-related genes (ARGs) in HCC data set from The Cancer Genome Atlas (TCGA). Multivariate cox regression was then performed to develop a risk prediction model for the prognosis of 370 HCC patients. The multi-target receiver operating characteristic (ROC) curve was used to determine the model’s accuracy. Besides, the relationship between drug sensitivity and ARGs expression was also examined.ResultsA total of 62 differentially expressed ARGs were identified in HCC patients. Univariate and multivariate regression identified five risk-associated ARGs (HDAC1, RHEB, ATIC, SPNS1 and SQSTM1) that were correlated with OS in HCC patients. Of importance, the risk-associated ARGs were independent risk factors in the multivariate risk model including clinical parameters such as malignant stage (HR?=?1.433, 95% CI?=?1.293–1.589, P?
WOS关键词POOR-PROGNOSIS ; HDAC1 EXPRESSION ; PROLIFERATION ; PROGRESSION ; METASTASIS ; TUMOR ; SENSITIVITY ; ACTIVATION ; APOPTOSIS ; INVASION
资助项目100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China[81803938] ; Anhui University of Traditional Chinese Medicine Natural Science Foundation[2018zryb48] ; Anhui University of Traditional Chinese Medicine Natural Science Foundation[2019zryb12]
WOS研究方向Oncology
语种英语
WOS记录号BMC:10.1186/S12885-020-07277-3
出版者BioMed Central
资助机构100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; Anhui University of Traditional Chinese Medicine Natural Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/42811]  
专题中国科学院合肥物质科学研究院
通讯作者Nie,Jinfu
作者单位1.Hefei Institutes of Physical Science, Chinese Academy of Sciences; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology
2.University of Science and Technology of China
3.Hefei Cancer Hospital, Chinese Academy of Sciences
4.the First Affiliated Hospital of Anhui University of Chinese Medicine; Experimental Center of Clinical Research
推荐引用方式
GB/T 7714		 Huo,Xingxing,Qi,Jian,Huang,Kaiquan,et al. Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients[J]. BMC Cancer,2020,20.
APA Huo,Xingxing.,Qi,Jian.,Huang,Kaiquan.,Bu,Su.,Yao,Wei.,...&Nie,Jinfu.(2020).Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients.BMC Cancer,20.
MLA Huo,Xingxing,et al."Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients".BMC Cancer 20(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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