Prognostic value of neutrophil-to-lymphocyte ratio in peripheral blood and pathological tissue in patients with esophageal squamous cell carcinoma
文献类型：期刊论文
| 作者 | Guo, Quanquan1; Shao, Zhiying2,3,4; Xu, Dan5; Fan, Lili5; Xiong, Huiru1; Ding, Xin6 ; You, Chuanwen1; Zhang, Longzhen6
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| 刊名 | MEDICINE
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| 出版日期 | 2020-07-17 |
| 卷号 | 99 |
| ISSN号 | 0025-7974 |
| 关键词 | blood routine esophageal squamous cell carcinoma immunohistochemistry neutrophil-to-lymphocyte ratio prognosis |
| DOI | 10.1097/MD.0000000000021306 |
| 通讯作者 | You, Chuanwen(sqycw@126.com) ; Zhang, Longzhen(jsxzzlz@126.com) |
| 英文摘要 | The aim of this study was to investigate the prognostic value of neutrophils-to-lymphocyte ratio in peripheral blood (NLR) and in cancer nest (iNLR) in patients with esophageal squamous cell carcinoma (ESCC). Totally 103 patients with ESCC treated with surgical radical surgery in the Shuyang People's Hospital from February 2010 to November 2014 were collected retrospectively. Peripheral blood routine test and immunohistochemistry examination of carcinoma nest were mainly performed. Survival rates were analyzed with Kaplan-Meier curves. Univariate analysis and multivariate analysis were also performed to explore potential prognostic factors of ESCC. The median survival time after surgery of low NLR group and high NLR group were 48 months and 30 months, respectively. The difference of overall survival between the 2 groups was statistically significant (chi(2) = 7.435,P = .006). The median survival time after surgery of low iNLR group and high iNLR group were 37 months and 24.5 months, respectively. The difference between the 2 groups was also statistically significant (chi(2) = 33.640,P = .000). Univariate analysis showed influence factors of postoperative survival in patients with ESCC included tumor-node-metastasis staging, NLR, iNLR, and grade of NLR score + iNLR score (P <= .05). Multivariate analysis confirmed NLR, iNLR, and tumor-node-metastasis staging were independent influence factors of postoperative survival in patients with ESCC (P <= .05). High level of NLR and iNLR implies a poor prognosis of ESCC. The application of both NLR and iNLR could guide clinicians to take aggressive treatments for high risk population. |
| WOS关键词 | RESPONSES ; REVEALS ; CANCER |
| 资助项目 | National Natural Science Foundation of China[81372424] ; Innovation Team Project of Jiangsu Province[CXTDA2017034] |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| WOS记录号 | WOS:000557513600122 |
| 资助机构 | National Natural Science Foundation of China ; Innovation Team Project of Jiangsu Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/44835]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | You, Chuanwen; Zhang, Longzhen |
| 作者单位 | 1.Xuzhou Med Univ, Dept Med Oncol, Affiliated Suqian Hosp, Suqian 223800, Jiangsu, Peoples R China 2.Univ Chinese Acad, Dept Intervent Ultrasound, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China 3.Inst Canc & Basic Med IBMC, Hangzhou, Zhejiang, Peoples R China 4.Chinese Acad Sci, Hangzhou, Zhejiang, Peoples R China 5.Xuzhou Med Univ, Dept Pathol, Affiliated Shuyang Hosp, Shuyang, Peoples R China 6.Xuzhou Med Univ, Dept Radiat Oncol, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Quanquan,Shao, Zhiying,Xu, Dan,et al. Prognostic value of neutrophil-to-lymphocyte ratio in peripheral blood and pathological tissue in patients with esophageal squamous cell carcinoma[J]. MEDICINE,2020,99. |
| APA | Guo, Quanquan.,Shao, Zhiying.,Xu, Dan.,Fan, Lili.,Xiong, Huiru.,...&Zhang, Longzhen.(2020).Prognostic value of neutrophil-to-lymphocyte ratio in peripheral blood and pathological tissue in patients with esophageal squamous cell carcinoma.MEDICINE,99. |
| MLA | Guo, Quanquan,et al."Prognostic value of neutrophil-to-lymphocyte ratio in peripheral blood and pathological tissue in patients with esophageal squamous cell carcinoma".MEDICINE 99(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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