Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer
文献类型：期刊论文
| 作者 | Li, Ming1,2,3; Shan, Wulin3; Hong, Bo1,4; Zou, Jinglu1,4; Li, Hong1,4 ; Han, Dandan3; Zhang, Yang3; Li, Lailing3; Li, Dan3; Lin, Wenchu1,4
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| 刊名 | SCIENTIFIC REPORTS
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| 出版日期 | 2020-07-29 |
| 卷号 | 10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-020-69615-6 |
| 通讯作者 | Lin, Wenchu(wenchu@hmfl.ac.cn) |
| 英文摘要 | miRNAs have been reported to be stably detectable in plasma and to function as potent biomarkers in multiple cancers. The study aimed to evaluate the expression of candidate circulating miRNAs in patients with small cell lung cancer (SCLC) to identify potential noninvasive biomarkers. The expression of five miRNAs (miR-92b, miR-146a, miR-375, miR-1224, and miR-1246) was significantly upregulated in plasma after chemoresistance induction. Receiver operating characteristic curve (ROC) analysis showed that the area under the curve (AUC) values of miR-92b and miR-375 were 0.766 and 0.791, respectively. The data demonstrated that among the five miRNAs assessed, these two miRNAs had better diagnostic accuracy for monitoring drug resistance. In addition, miR-92b and miR-375 levels were decreased after effective chemotherapy. Furthermore, Kaplan-Meier survival analysis confirmed that high expression of miR-92b and miR-375 was closely related to shorter progression-free survival (PFS) in SCLC patients. In conclusion, these findings indicate that circulating miR-92b and miR-375 might be ideal noninvasive biomarkers for monitoring drug resistance during chemotherapy and evaluating the prognosis of patients with SCLC. |
| WOS关键词 | MICRORNAS ; BIOMARKER ; DIAGNOSIS |
| 资助项目 | National Natural Science Foundation of China[81672647] ; National Natural Science Foundation of China[81972191] ; Fundamental Research Funds for Central University[WK9110000025] ; National Cancer Center Climbing Foundation[NCC201812B036] ; Science and Technology Major Project of Anhui Province[18030801140] ; Key Program of the 13th Five-year Plan of CASHIPS[KP-2017-26] ; 100-Talent Program of the Chinese Academy of Sciences ; High Magnetic Field Laboratory of Anhui Province |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000556385700018 |
| 出版者 | NATURE PUBLISHING GROUP |
| 资助机构 | National Natural Science Foundation of China ; Fundamental Research Funds for Central University ; National Cancer Center Climbing Foundation ; Science and Technology Major Project of Anhui Province ; Key Program of the 13th Five-year Plan of CASHIPS ; 100-Talent Program of the Chinese Academy of Sciences ; High Magnetic Field Laboratory of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/45051]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lin, Wenchu |
| 作者单位 | 1.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230036, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Lab Diagnost, Hefei 230031, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ming,Shan, Wulin,Hong, Bo,et al. Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer[J]. SCIENTIFIC REPORTS,2020,10. |
| APA | Li, Ming.,Shan, Wulin.,Hong, Bo.,Zou, Jinglu.,Li, Hong.,...&Lin, Wenchu.(2020).Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer.SCIENTIFIC REPORTS,10. |
| MLA | Li, Ming,et al."Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer".SCIENTIFIC REPORTS 10(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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