Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment
文献类型：期刊论文
| 作者 | Qu, Ding1,2; Qin, Yue2,3; Liu, Yuping1,2; Liu, Tingting1; Liu, Congyan1,2; Han, Tao1; Chen, Yan1,2; Ma, Chengyao1,2; Li, Xiaoqi1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2020-07-22 |
| 卷号 | 12 |
| 关键词 | tumor immune microenvironment fever-inducible nanocomposite vascular normalization TAMs reprogramming breast cancer therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.0c06949 |
| 通讯作者 | Qu, Ding(quding1985@hotmail.com) ; Chen, Yan(ychen202@hotmail.com) |
| 英文摘要 | A fever-mimic response capable of recruiting reprogrammed macrophages holds great potential in the engineering of the tumor microenvironment (TME). Low-temperature photothermal therapy (LT-PTT) can maintain tumors at a fever-like temperature (<45 degrees C) temporarily; however, it still faces several challenges in efficient regulation of TME because of reciprocal cross-talk between the bypass pathways. Here, we report a synergistic engineering of TME through an enhanced activation of a fever-mimic response based on both LT-PTT and tumor vascular normalization. Such engineering is achieved by a fever-inducible lipid nanocomposite (GNR-T/CM-L), which produces mild heat (similar to 43 degrees C) and sequentially releases multicomponents to cooperatively upregulate interferon-gamma under NIR irradiation, forming a bidirectionally closed loop for downstream M1 tumor-associated macrophage polarization and promoting the inhibition of the tumor growth. In proof-of-concept studies, GNR-T/CM-L demonstrated efficient tumor ablation in breast tumor xenograft-bearing mice and significantly prolonged their survival period. It paves an avenue to precisely reprogram TME for efficient cancer therapy through synergistic pathways of creating fever-like responses in the tumor. |
| WOS关键词 | VASCULAR NORMALIZATION ; GOLD NANORODS ; MACROPHAGES ; HYPOXIA ; ACTIVATION ; IMMUNITY |
| 资助项目 | National Natural Science Foundation of China[81873017] ; Key Medical Youth Talent Project of Jiangsu Province[QNRC2016631] ; Six Talent Peak Project of Jiangsu Province[YY-0282019] ; Key Research Project of Jiangsu Provincial Academy of Traditional Chinese Medicine[BM2018024-2019002] ; Jiangsu Government Scholarship for Overseas Studies |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000555417200008 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Key Medical Youth Talent Project of Jiangsu Province ; Six Talent Peak Project of Jiangsu Province ; Key Research Project of Jiangsu Provincial Academy of Traditional Chinese Medicine ; Jiangsu Government Scholarship for Overseas Studies |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/45120]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Qu, Ding; Chen, Yan |
| 作者单位 | 1.Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Peoples R China 2.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Peoples R China 3.Chinese Acad Sci, Canc Hosp, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Ding,Qin, Yue,Liu, Yuping,et al. Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12. |
| APA | Qu, Ding.,Qin, Yue.,Liu, Yuping.,Liu, Tingting.,Liu, Congyan.,...&Li, Xiaoqi.(2020).Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Qu, Ding,et al."Fever-Inducible Lipid Nanocomposite for Boosting Cancer Therapy through Synergistic Engineering of a Tumor Microenvironment".ACS APPLIED MATERIALS & INTERFACES 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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