Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck
文献类型：期刊论文
| 作者 | Xu, Qiang2,3; Fang, Meiyu1,3; Zhu, Jing3,4; Dong, Haoru5; Cao, Jun1,3; Yan, Lin6; Leonard, Fransisca7; Oppel, Felix8; Sudhoff, Holger8; Kaufmann, Andreas M.9,10,11,12 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
 |
| 出版日期 | 2020 |
| 卷号 | 16 |
| 关键词 | nanotherapeutics drug delivery cancer immunotherapy nanovaccine head and neck squamous cell carcinoma human papillomavirus |
| ISSN号 | 1449-2288 |
| DOI | 10.7150/ijbs.47068 |
| 通讯作者 | Qian, Xu(qian_michelle2014@163.com) |
| 英文摘要 | Immunotherapies such as immune checkpoint blockade benefit only a portion of patients with head and neck squamous cell carcinoma. The multidisciplinary field of nanomedicine is emerging as a promising strategy to achieve maximal anti-tumor effect in cancer immunotherapy and to turn non-responders into responders. Various methods have been developed to deliver therapeutic agents that can overcome bio-barriers, improve therapeutic delivery into the tumor and lymphoid tissues and reduce adverse effects in normal tissues. Additional modification strategies also have been employed to improve targeting and boost cytotoxic T cell-based immune responses. Here, we review the state-of-the-art use of nanotechnologies in the laboratory, in advanced preclinical phases as well as those running through clinical trials assessing their advantages and challenges. |
| WOS关键词 | NANOPARTICLE VACCINE ; NAB-PACLITAXEL ; OPEN-LABEL ; CANCER ; DELIVERY ; EFFICACY ; PEPTIDE ; POTENT ; DNA ; CISPLATIN |
| 资助项目 | National Natural Science Foundation of China[81702091] ; Medical and the Health Science Project of Zhejiang Province[2019KY327] ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000555111400003 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | National Natural Science Foundation of China ; Medical and the Health Science Project of Zhejiang Province ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/45143]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Qian, Xu |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Lab, Hangzhou, Peoples R China 5.Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Peoples R China 6.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 7.Houston Methodist Res Inst, Dept Nanomed, Houston, TX USA 8.Klinikum Bielefeld, Dept Otolaryngol Head & Neck Surg, Bielefeld, Germany 9.Charite Univ Med Berlin, Clin Gynecol, Berlin, Germany 10.Free Univ Berlin, Berlin, Germany |
| 推荐引用方式 GB/T 7714 | Xu, Qiang,Fang, Meiyu,Zhu, Jing,et al. Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2020,16. |
| APA | Xu, Qiang.,Fang, Meiyu.,Zhu, Jing.,Dong, Haoru.,Cao, Jun.,...&Qian, Xu.(2020).Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,16. |
| MLA | Xu, Qiang,et al."Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 16(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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