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Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window

文献类型：期刊论文

作者Zhang, Ya2; Wang, Yingjie3; Yang, Xueqin2; Yang, Qinglai2; Li, Juan2,3; Tan, Weihong1,2,4
刊名SMALL
出版日期2020-08-06
ISSN号1613-6810
关键词enzymatic polymerization photoacoustic imaging photothermal-chemo synergistic therapy polyaniline second near-infrared window
DOI10.1002/smll.202001177
通讯作者Yang, Qinglai(qingyu513@126.com) ; Li, Juan(lijuan@fzu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要Photoacoustic imaging-guided photothermal therapy in the second near-infrared (NIR-II) window shows promise for clinical deep-penetrating tumor phototheranostics. However, ideal photothermal agents in the NIR-II window are still rare. Here, the emeraldine salt of polyaniline (PANI-ES), especially synthesized by a one-pot enzymatic reaction on sodium bis(2-ethylhexyl) sulfosuccinate (AOT) vesicle surface (PANI-ES@AOT, lambda(max) approximate to 1000 nm), exhibits excellent dispersion in physiological environment and remarkable photothermal ability at pH 6.5 (photothermal conversion efficiency of 43.9%). As a consequence of the enhanced permeability and retention effect of tumors and the doping-induced photothermal effect of PANI-ES@AOT, this pH-sensitive NIR-II photothermal agent allows tumor acidity phototheranostics with minimized pseudosignal readout and subdued normal tissue damage. Moreover, the enhanced fluidity of vesicle membrane triggered by heating is beneficial for drug release and allows precise synergistic therapy for an improved therapeutic effect. This study highlights the potential of template-oriented (or interface-confined) enzymatic polymerization reactions for the construction of conjugated polymers with desired biomedical applications.
WOS关键词AOT VESICLES ; POLYMERIZATION ; NANOPARTICLES
资助项目National Natural Science Foundation of China[91959102] ; Natural Science Foundation of Fujian Province of China[2017J06004] ; Shanghai Rising-Star Program[19QA1405400]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000555957400001
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province of China ; Shanghai Rising-Star Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/45159]  
专题中国科学院合肥物质科学研究院
通讯作者Yang, Qinglai; Li, Juan; Tan, Weihong
作者单位1.Hunan Univ, Aptamer Engn Ctr Hunan Prov, Coll Biol,Mol Sci & Biomed Lab MBL, Coll Chem & Chem Engn,State Key Lab Chemo Biosens, Changsha 410082, Hunan, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp,Coll Chem & Chem, Inst Mol Med IMM,State Key Lab Oncogenes & Relate, Shanghai 200240, Peoples R China
3.Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm,MO, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Fuzhou 350108, Peoples R China
4.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ya,Wang, Yingjie,Yang, Xueqin,et al. Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window[J]. SMALL,2020.
APA Zhang, Ya,Wang, Yingjie,Yang, Xueqin,Yang, Qinglai,Li, Juan,&Tan, Weihong.(2020).Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window.SMALL.
MLA Zhang, Ya,et al."Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window".SMALL (2020).

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来源：合肥物质科学研究院

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