Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T
文献类型：期刊论文
| 作者 | Wen, Qingqing2; Yang, Hongyi2,3; Li, Jiali4; Zhang, Jin2 ; Tong, Haiyang2; Ye, Qiong2; Zhong, Kai1,2,3,5
|
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2020-08-14 |
| 卷号 | 12 |
| 关键词 | quantitative susceptibility mapping iron concentration brain aging rhesus monkey high resolution 9 4 T |
| ISSN号 | 1663-4365 |
| DOI | 10.3389/fnagi.2020.00259 |
| 通讯作者 | Ye, Qiong(qiong.ye@hmfl.ac.cn) |
| 英文摘要 | Iron concentration in the brain has been suggested as a biomarker of pathologic neurodegeneration. However, the iron concentration changes in healthy aging as well. This study aimed to quantify the age-related changes in iron concentration in the gray matter of healthy rhesus monkeys using quantitative susceptibility mapping (QSM). Three-dimensional gradient-echo images of 16 female rhesus monkey brains aged between 2 and 26 years were acquiredin vitro. The susceptibilities in the brain regions of the caudate nucleus (Cd), putamen (Pt), globus pallidus (Gp), and substantia nigra (Sn) were analyzed. The susceptibility varied across different brain regions, with higher levels in the Gp and Sn. Susceptibilities in all analyzed brain regions were linearly correlated with age, yet the plateau period as observed in human brains was absent. This is the firstin vitroreport of the age-related variability of susceptibility in the deep gray matter of rhesus monkey brains at 9.4 T, with an isotropic resolution of 150 mu m. Awareness of age-related changes in susceptibility is vital for the establishment of a baseline to facilitate the differentiation of pathologic neurodegeneration from healthy aging in non-human primate studies. |
| WOS关键词 | ENABLED DIPOLE INVERSION ; IRON CONCENTRATION ; MAGNETIC-FIELD ; PRIMATE MODELS ; MAPPING QSM ; PHASE DATA ; MRI ; RECONSTRUCTION ; VALIDATION ; COSMOS |
| 资助项目 | National Natural Science Foundation of China[91649101] ; National Key Research and Development Program of China[2018YFE0205700] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; Hefei Science Center[2017HSCKPRD003] ; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences ; Yunnan Province |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000566190400001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Hefei Science Center ; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences ; Yunnan Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70331]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Ye, Qiong |
| 作者单位 | 1.Key Lab Anhui Prov High Field Magnet Resonance Im, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Peoples R China 3.Univ Sci & Technol China, Hefei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Qingqing,Yang, Hongyi,Li, Jiali,et al. Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T[J]. FRONTIERS IN AGING NEUROSCIENCE,2020,12. |
| APA | Wen, Qingqing.,Yang, Hongyi.,Li, Jiali.,Zhang, Jin.,Tong, Haiyang.,...&Zhong, Kai.(2020).Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T.FRONTIERS IN AGING NEUROSCIENCE,12. |
| MLA | Wen, Qingqing,et al."Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T".FRONTIERS IN AGING NEUROSCIENCE 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。