Impact of Radiation Dose on Survival for Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemoradiotherapy
文献类型：期刊论文
| 作者 | Yang, Yang2,3; Xu, Xiaofang1,3; Zhou, Xia2,3; Bao, Wuan2,3; Zhang, Danhong2,3; Gu, Feiying2,3; Du, Xianghui2,3; Chen, Qixun1,3; Qiu, Guoqin2,3 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2020-08-20 |
| 卷号 | 10 |
| ISSN号 | 2234-943X |
| 关键词 | esophageal cancer neoadjuvant chemoradiotherapy surgery radiation dose trimodality cancer treatment |
| DOI | 10.3389/fonc.2020.01431 |
| 通讯作者 | Chen, Qixun(chenqx@zjcc.org.cn) ; Qiu, Guoqin(qiugq@zjcc.org.cn) |
| 英文摘要 | Purpose:Radiation dose used in the neoadjuvant chemoradiotherapy (NCRT) for patients with locally advanced esophageal squamous cell carcinoma (ESCC) varies in different trials and clinical practice. Methods and Materials:Data from patients diagnosed with ESCC receiving NCRT followed by esophagectomy were retrospectively collected from February 2013 to December 2017. Lower dose (LD) radiotherapy was defined as <= 45 Gy, and >45 Gy was considered as higher dose (HD). Survival rates were calculated by the Kaplan-Meier method and compared with long-rank test. Multivariate Cox regression analyses were performed to identify variables associated with survival. Results:A total of 118 patients treated with NCRT were included in our analysis: 62 patients received LD radiotherapy, and 56 patients received HD radiotherapy. The median follow-up time was 24.3 months (0.67-65.3 m). Two-years overall survival (OS) rates were 75.0 and 79.0% in HD and LD group, respectively (P= 0.360), and complete pathological remission (pCR) rates in two groups were 42.9 and 30.6%, respectively (P= 0.17). The incidences of toxic effects including post-operative complications were not significantly different between two groups. Multivariate analysis showed that tumor T stage, M1a disease, smoking history, and pCR rate were significantly associated with OS. Conclusions:In ESCC patients treated with NCRT followed by surgery, higher radiation dose was not significantly associated with a higher pCR rate and longer survival. Lower radiation dose might be a preferable time-dose fraction scheme. Our finding needs to be further validated by randomized trials. |
| WOS关键词 | PHASE-III TRIAL ; LUNG-CANCER ; THERAPY ; CHEMOTHERAPY ; CHEMORADIATION ; FRACTIONATION ; RESECTION |
| 资助项目 | National Natural Science Foundation of China[81702968] ; Zhejiang Province Medical and Health Science and Technology Project[2020365447] ; Zhejiang Province Medical and Health Science and Technology Project[2017192527] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000566183000001 |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Province Medical and Health Science and Technology Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70337]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Qixun; Qiu, Guoqin |
| 作者单位 | 1.Univ Chinese Acad Sci, Canc Hosp, Dept Thorac Surg, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Thorac Radiotherapy, Canc Hosp, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yang,Xu, Xiaofang,Zhou, Xia,et al. Impact of Radiation Dose on Survival for Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemoradiotherapy[J]. FRONTIERS IN ONCOLOGY,2020,10. |
| APA | Yang, Yang.,Xu, Xiaofang.,Zhou, Xia.,Bao, Wuan.,Zhang, Danhong.,...&Qiu, Guoqin.(2020).Impact of Radiation Dose on Survival for Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemoradiotherapy.FRONTIERS IN ONCOLOGY,10. |
| MLA | Yang, Yang,et al."Impact of Radiation Dose on Survival for Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemoradiotherapy".FRONTIERS IN ONCOLOGY 10(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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