Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy
文献类型：期刊论文
| 作者 | Yang, Yu2,3,4,5 ; Sun, Xiaoqi6; Xu, Jun7; Cui, Cheng4,5; Yazd, Hoda Safari4; Pan, Xiaoshu4; Zhu, Yujie7; Chen, Xigao4,5; Li, Xiaowei4,5; Li, Jin1,8,9
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| 刊名 | ACS NANO
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| 出版日期 | 2020-08-25 |
| 卷号 | 14 |
| 关键词 | recognition-then-activation circular bispecific aptamer cb-aptamer adoptive T cell immunotherapy T cell immunotherapy on shelf |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b09884 |
| 通讯作者 | Cui, Cheng(cuichengcuicheng@gmail.com) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Adoptive T cell immunotherapy, such as chimeric antigen receptor (CAR) T cell therapy, has proven to be highly efficient in the treatment of hematologic malignancies. However, it is challenged by complicated ex vivo engineering, systemic side effects, and low expression of tumor-specific antigen, especially in solid tumors. In this paper, we present a "recognition-then-activation" strategy, which first assists naive T cells to recognize and adhere to cancer cells and then activates the accumulated T cell in situ to specifically kill cancer cells. In this way, we could unleash the antitumor power of the T cell without complicated and time-consuming cell engineering. To this end, circular bispecific aptamers (cb-aptamers), a class of chemically cyclized aptamers with improved stability and molecular recognition ability which can simultaneously bind to two different types of cells, were first constructed to form artificial intercellular recognition between naive T cells and tumor cells. After T cell accumulation in the tumor mediated by cb-aptamers, T cells in the tumor site were subsequently activated in situ via commercial CD3/CD28 T cell activator beads to induce tumor-specific killing. Furthermore, by simply choosing different anticancer aptamers, the application of this "recognition-then-activation" strategy can be expanded for targeted treatment of various types of cancer. This may represent a simple T cell immunotherapy that is useful for the treatment of multiple cancers. |
| WOS关键词 | CANCER-IMMUNOTHERAPY ; ADOPTIVE IMMUNOTHERAPY ; ANTIBODIES ; RECEPTOR ; THERAPY ; SELECTION ; MELANOMA ; ANTIGENS ; B7-H1 |
| 资助项目 | National Institutes of Health[GM079359] ; National Institutes of Health[P0077690] ; National Institutes of Health[CA133086] ; NSFC[21505032] ; NSFC[21325520] ; NSFC[1327009] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000566341000025 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Institutes of Health ; NSFC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70454]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cui, Cheng; Tan, Weihong |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med IMM,Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China 4.Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Hlth Canc Ctr,UF Genet Inst,Dept Physiol & Funct, Gainesville, FL 32611 USA 5.Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA 6.Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA 7.Soochow Univ, Inst Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Peoples R China 8.Hunan Univ, Coll Chem & Chem Engn,Coll Biol, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China 9.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yu,Sun, Xiaoqi,Xu, Jun,et al. Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy[J]. ACS NANO,2020,14. |
| APA | Yang, Yu.,Sun, Xiaoqi.,Xu, Jun.,Cui, Cheng.,Yazd, Hoda Safari.,...&Tan, Weihong.(2020).Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy.ACS NANO,14. |
| MLA | Yang, Yu,et al."Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy".ACS NANO 14(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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