Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
文献类型：期刊论文
| 作者 | Yu, De-Hua1; Xu, Zhi-Yuan2; Mo, Shaowei3; Yuan, Li3; Cheng, Xiang-Dong2; Qin, Jiang-Jiang1,2 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2020-08-05 |
| 卷号 | 10 |
| 关键词 | MDMX MDM2 p53 oncogene tumor suppressor inhibitors |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2020.01389 |
| 通讯作者 | Qin, Jiang-Jiang(jqin@zcmu.edu.cn) |
| 英文摘要 | The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is often amplified and highly expressed in human cancers, promotes cancer cell growth, and inhibits apoptosis by dampening p53-mediated transcription of its target genes. Inhibiting MDMX-p53 interaction has been found to be effective for restoring the tumor suppressor activity of p53. Therefore, MDMX is becoming one of the most promising molecular targets for developing anticancer therapeutics. In the present review, we mainly focus on the current MDMX-targeting strategies and known MDMX inhibitors, as well as their mechanisms of action andin vitroandin vivoanticancer activities. We also propose other potential targeting strategies for developing more specific and effective MDMX inhibitors for cancer therapy. |
| WOS关键词 | HDMX-MEDIATED SUPPRESSION ; SMALL-MOLECULE ; MESSENGER-RNA ; RING DOMAIN ; P53-BINDING PROTEIN ; GENE AMPLIFICATION ; COLORECTAL-CANCER ; MALIGNANT GLIOMAS ; ONCOPROTEIN MDM2 ; P53 STABILITY |
| 资助项目 | National Natural Science Foundation of China[81903842] ; National Natural Science Foundation of China[81573953] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2020ZZ005] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2016ZZ012] ; Zhejiang Chinese Medical University[111100E014] ; Medical Science and Technology Project of Zhejiang Province[WKJ-ZJ-1728] ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province[2018ZY006] ; Science and Technology Projects of Zhejiang Province[2019C03049] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000563501700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan ; Zhejiang Chinese Medical University ; Medical Science and Technology Project of Zhejiang Province ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province ; Science and Technology Projects of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70463]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Qin, Jiang-Jiang |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Chinese Acad Sci, Inst Canc & Basic Med,Canc Hosp, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, De-Hua,Xu, Zhi-Yuan,Mo, Shaowei,et al. Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges[J]. FRONTIERS IN ONCOLOGY,2020,10. |
| APA | Yu, De-Hua,Xu, Zhi-Yuan,Mo, Shaowei,Yuan, Li,Cheng, Xiang-Dong,&Qin, Jiang-Jiang.(2020).Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges.FRONTIERS IN ONCOLOGY,10. |
| MLA | Yu, De-Hua,et al."Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges".FRONTIERS IN ONCOLOGY 10(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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