Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
文献类型：期刊论文
| 作者 | Li, Long4; Xu, Shujuan4,5; Yan, He4,5; Li, Xiaowei4; Yazd, Hoda Safari4; Li, Xiang4; Huang, Tong4 ; Cui, Cheng1,3,5; Jiang, Jianhui5; Tan, Weihong2,4,5,6
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2020-08-13 |
| ISSN号 | 1433-7851 |
| 关键词 | aptamers artificial bases biomarker discovery cancer classification SELEX |
| DOI | 10.1002/anie.202003563 |
| 通讯作者 | Cui, Cheng(cuichengchem@163.com) ; Jiang, Jianhui(jianhuijian@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | The advent of SELEX (systematic evolution of ligands by exponential enrichment) technology has shown the ability to evolve artificial ligands with affinity and specificity able to meet growing clinical demand for probes that can, for example, distinguish between the target leukemia cells and other cancer cells within the matrix of heterogeneity, which characterizes cancer cells. Though antibodies are the conventional and ideal choice as a molecular recognition tool for many applications, aptamers complement the use of antibodies due to many unique advantages, such as small size, low cost, and facile chemical modification. This Minireview will focus on the novel applications of aptamers and SELEX, as well as opportunities to develop molecular tools able to meet future clinical needs in biomedicine. |
| WOS关键词 | IN-VITRO SELECTION ; ELECTROPHORESIS-SELEX SELECTION ; EXPONENTIAL ENRICHMENT ; SYSTEMATIC EVOLUTION ; DNA APTAMERS ; CANCER-CELLS ; RNA ; RECOGNITION ; LIGANDS ; GENERATION |
| 资助项目 | NSFC[NSFC 21827811] ; NSFC[61527806] ; Science and Technology Project of Hunan Province[2017XK2103] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000558834000001 |
| 资助机构 | NSFC ; Science and Technology Project of Hunan Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70764]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cui, Cheng; Jiang, Jianhui; Tan, Weihong |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China 2.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 4.Univ Florida, Ctr Res Bio Nano Interface, Hlth Canc Ctr, UF Genet Inst,Dept Chem & Physiol & Funct Genom, Gainesville, FL 32611 USA 5.Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Biol,Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,Coll Chem & Chem Engn, Changsha 410082, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Inst Mol Med IMM, Renji Hosp,State Key Lab Oncogenes & Related Gene, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Long,Xu, Shujuan,Yan, He,et al. Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020. |
| APA | Li, Long.,Xu, Shujuan.,Yan, He.,Li, Xiaowei.,Yazd, Hoda Safari.,...&Tan, Weihong.(2020).Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. |
| MLA | Li, Long,et al."Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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