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Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme

文献类型：期刊论文

作者Chen, Xueran5,6; Li, Hao1; Fan, Xiaoqing2,3; Zhao, Chenggang1,5; Ye, Kaiqin5,6; Zhao, Zhiyang1,5; Hu, Lizhu1,5; Ma, Huihui4; Wang, Hongzhi5,6; Fang, Zhiyou5,6
刊名MOLECULAR THERAPY-ONCOLYTICS
出版日期2020-06-26
卷号17
ISSN号2372-7705
DOI10.1016/j.omto.2020.05.007
通讯作者Chen, Xueran(xueranchen@cmpt.ac.cn) ; Fang, Zhiyou(z.fang@cmpt.ac.cn)
英文摘要Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression in GBM. The role of protein palmitoylation in GBM, however, has not been systematically reported. This study aimed to investigate the effect of protein palmitoylation on GBM cell survival and the cell cycle. In this study, most palmitoyltransferases were upregulated in GBM and its cell lines, and protein palmitoylation participated in signaling pathways controlling cell survival and the GBM cell cycle. Inhibition of protein palmitoylation with substrate-analog inhibitors, that is, 2-bromopalmitate, cerulenin, and tunicamycin, induced G(2) cell cycle arrest and cell death in GBM cells through enhanced endoplasmic reticulum (ER) stress. These effects are primarily attributed to the palmitoylation inhibitors activating pro-apoptotic pathways and ER stress signals. Further analysis revealed was the accumulation of SUMOylated XBP1 (X-box binding protein 1) and its transcriptional repression, along with a reduction in XBP1 palmitoylation. Taken together, the present results indicate that protein palmitoylation plays an important role in the survival of GBM cells, further providing a potential therapeutic strategy for GBM.
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; 2-BROMOPALMITATE ; ACTIVATION ; RESISTANCE ; ACYLATION ; CERULENIN ; PATHWAY ; ANALOGS ; BRANCH
资助项目National Natural Science Foundation of China[81872066] ; National Natural Science Foundation of China[31571433] ; National Natural Science Foundation of China[81773131] ; National Natural Science Foundation of China[81972635] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2018CXFX004] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2017FXCX008] ; CASHIPS Director's Fund[YZJJ201704] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2018487]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000544101600045
出版者CELL PRESS
资助机构National Natural Science Foundation of China ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; CASHIPS Director's Fund ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/71211]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Xueran; Fang, Zhiyou
作者单位1.Univ Sci & Technol China, Sch Life Sci, 96 JinZhai Rd, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China USTC, Div Life Sci & Med, Affiliated Hosp USTC 1, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China
3.Anhui Prov Hosp, Dept Anesthesiol, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, 218 JiXi Rd, Hefei 230031, Anhui, Peoples R China
5.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Ctr Med Phys & Technol, Hefei Inst Phys Sci, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
6.Chinese Acad Sci, Hefei Canc Hosp, Dept Mol Pathol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xueran,Li, Hao,Fan, Xiaoqing,et al. Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme[J]. MOLECULAR THERAPY-ONCOLYTICS,2020,17.
APA Chen, Xueran.,Li, Hao.,Fan, Xiaoqing.,Zhao, Chenggang.,Ye, Kaiqin.,...&Fang, Zhiyou.(2020).Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme.MOLECULAR THERAPY-ONCOLYTICS,17.
MLA Chen, Xueran,et al."Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme".MOLECULAR THERAPY-ONCOLYTICS 17(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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