Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles
文献类型：期刊论文
| 作者 | Wang Xue2 ; Cheng Wenge4; Yang Qiuyuan2; Niu Hongyun2; Liu Qian2; Liu Yun2; Gao Ming2; Xu Ming2; Xu An2; Liu Sijin2
|
| 刊名 | Journal of Environmental Sciences
 |
| 出版日期 | 2018 |
| 卷号 | 69 |
| 关键词 | F-19 MAGNETIC-RESONANCE GRAPHENE OXIDE PERFLUOROOCTANE SULFONATE IN-VITRO CELLS TOXICITY DAMAGE LIVER METABOLISM MECHANISMS Fluorinated nanoparticles Polymer Cytotoxicity Oxidative stress Health risk |
| ISSN号 | 1001-0742 |
| 其他题名 | Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles |
| 英文摘要 | As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles, trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles (PTFE-PMMA NPs) were synthesized with various fluorine contents (PTFE-PMMA-1 NPs 12.0 wt.%, PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine (F) contents and F-containing side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose (50 mu g/mL) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species (ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials (ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. (c) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6273874 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/93935]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 作者单位 | 1.Key Laboratory of Organofluorine Chemistry and Laboratory of Polymer Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; 2.State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; 3.School of Physical Science and Technology, Shanghai Tech University, Shanghai 201210, China; 4.University of Chinese Academy of Sciences, Beijing 100049, China; 5.School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; 6.Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei 230031, China; |
| 推荐引用方式 GB/T 7714 | Wang Xue,Cheng Wenge,Yang Qiuyuan,et al. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles[J]. Journal of Environmental Sciences,2018,69. |
| APA | Wang Xue.,Cheng Wenge.,Yang Qiuyuan.,Niu Hongyun.,Liu Qian.,...&Du Yuguo.(2018).Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.Journal of Environmental Sciences,69. |
| MLA | Wang Xue,et al."Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles".Journal of Environmental Sciences 69(2018). |
入库方式： OAI收割
来源：合肥物质科学研究院
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