The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion
文献类型：期刊论文
| 作者 | Zhu, Mengting2; Zheng, Weihui1,3,4; Xiang, Yangfeng1,3,4; Gu, Jialei1,3,4; Wang, Kejing1,3,4; Shang, Jinbiao1,3,4 |
| 刊名 | GLAND SURGERY
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 9 |
| 关键词 | Papillary thyroid microcarcinoma (PTMC) distance thyroid capsule central lymph node metastasis predictive factors |
| ISSN号 | 2227-684X |
| DOI | 10.21037/gs-20-478 |
| 通讯作者 | Shang, Jinbiao(shangjb@zjcc.org.cn) |
| 英文摘要 | Background: This study aims to explore the predictive factors of central lymph node metastasis (CLNM) in patients with papillary thyroid microcarcinoma (PTMC) without capsule invasion. Methods: From January 2016 to October 2018, 1,622 patients with PTMC, who underwent surgical treatment at Zhejiang Cancer Hospital, were enrolled in the present study. A model of multivariate logistic regression was developed to find the variables that were independently associated with CLNM. The results were presented in the odds ratio (OR) with a 95% confidence interval (CI). The nomogram for predicting CLNM was developed based on the results of the multivariate logistic regression analysis. The distance (distance >0) from tumor to capsule is defined as the shortest distance from the tumor boundary to the capsule or trachea. Result: The multivariate logistic regression analysis indicated that age, gender, tumor maximum diameter, tumor mean diameter, and tumor volume were independently associated with CLNM. In the 692 cases without capsular invasion, the distance from the capsule was not correlated to the CLNM. The joint model, which included age, gender, tumor volume, and capsular invasion, were analyzed using the ROC curve. The cut-off point for the prediction of CLNM was defined as a value of 0.208. The area under the ROC curve was 0.687, the sensitivity was 65.4%, and the specificity was 63.3%. Conclusions: Gender, age, maximum diameter, mean diameter, tumor volume, and capsular invasion were independently associated with the CLNM. When there was no capsular invasion, the distance between the tumor and capsule was not correlated to the CLNM, suggesting that considering whether the tumor is dose to the capsule may not be necessary for low-risk PTMC. |
| WOS关键词 | RISK-FACTORS ; PATHOLOGICAL PREDICTORS ; SONOGRAPHIC FEATURES ; ACTIVE SURVEILLANCE ; DISSECTION ; RECURRENCE ; MANAGEMENT ; FREQUENCY ; PATTERN ; CANCER |
| 资助项目 | Zhejiang Provincial Natural Science Foundation of China[LY20H160007] |
| WOS研究方向 | Surgery |
| 语种 | 英语 |
| WOS记录号 | WOS:000544808800016 |
| 出版者 | AME PUBL CO |
| 资助机构 | Zhejiang Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/94796]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Shang, Jinbiao |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China 4.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Mengting,Zheng, Weihui,Xiang, Yangfeng,et al. The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion[J]. GLAND SURGERY,2020,9. |
| APA | Zhu, Mengting,Zheng, Weihui,Xiang, Yangfeng,Gu, Jialei,Wang, Kejing,&Shang, Jinbiao.(2020).The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion.GLAND SURGERY,9. |
| MLA | Zhu, Mengting,et al."The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion".GLAND SURGERY 9(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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