Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides
文献类型：期刊论文
| 作者 | Bai, Huarong3; Jin, Cheng3,4; Zou, Jianmei3; Wang, Ruowen4; Fu, Ting1,2; Tan, Weihong3,4 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2020-08-04 |
| 卷号 | 92 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.0c00614 |
| 通讯作者 | Fu, Ting(futinghnu@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Artificial bases have emerged as a useful tool to expand genetic alphabets and biomedical applications of oligonucleotides. Herein, we reported that the conformation conversion enhances cellular uptake of hydrophobic 3,5-bis(trifluoromethyl)benzene (F) base double-strand-conjugated oligonucleotides. The formation of the F base double-strand caged the hydrophobic F base in the duplex strand, thus preventing F base from interacting with cells to some extent. However, upon conversion of F base double-strand-conjugated oligonucleotide to F base single-strand-conjugated oligonucleotide, F bases then were allowed to interact with cells by stronger hydrophobic interactions, followed by cellular uptake. The results were concluded as a pairing-induced cage effect of F base and have the potential for the construction of stimuli-responsive cellular uptake of functional nucleic acids. |
| WOS关键词 | SEMISYNTHETIC ORGANISM ; EVOLUTION |
| 资助项目 | China NSFC[NSFC 21521063] ; China NSFC[NSFC 21327009] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000558761500028 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | China NSFC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/102915]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fu, Ting; Tan, Weihong |
| 作者单位 | 1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China 3.Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov,Coll Biol, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Hunan, Peoples R China 4.Shanghai Jiao Tong Univ, Inst Mol Med IMM, Renji Hosp, State Key Lab Oncogenes & Related Genes, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Huarong,Jin, Cheng,Zou, Jianmei,et al. Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides[J]. ANALYTICAL CHEMISTRY,2020,92. |
| APA | Bai, Huarong,Jin, Cheng,Zou, Jianmei,Wang, Ruowen,Fu, Ting,&Tan, Weihong.(2020).Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides.ANALYTICAL CHEMISTRY,92. |
| MLA | Bai, Huarong,et al."Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides".ANALYTICAL CHEMISTRY 92(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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