Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy
文献类型：期刊论文
| 作者 | Qin, Yue1,2,3; Liu, Tingting1; Guo, Mengfei1; Liu, Yuping1,2; Liu, Congyan1,2; Chen, Yan1,2; Qu, Ding1,2 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2020-07-21 |
| 卷号 | 8 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/d0bm00498g |
| 通讯作者 | Chen, Yan() ; Qu, Ding(quding1985@hotmail.com) |
| 英文摘要 | Increasing evidence indicates that the tumor microenvironment (TME) imposes various obstacles in response to chemotherapies. Sodium tanshinone IIA sulfonate (STS) has a validated ability to repair the unfavorable TME, providing a suitable environment for celastrol-based chemotherapy. However, remodeling TME still possesses enormous challenges for STS due to the difficulty in a controlled release at tumor sites. Gold nanorods (GNRs) capable of converting near-infrared (NIR) light into heat offer a promising trigger approach to regulate the local drug release. Here, we fabricated a gold nanorod-anchored thermosensitive liposomal complex co-loaded with STS and celastrol (G-T/C-L), which could sequentially release STS and celastrol upon NIR irradiation at 808 nm. When G-T/C-L reaches the sites, NIR illumination produces mild heat (similar to 43 degrees C) and thereby triggers a rapid release of STS in the initial stage, decreasing the level of tumoral blood vessels, collagen, cancer-associated fibroblasts, and Th2 type cytokines. In the subsequent stage, celastrol was unloaded to exert an anticancer effect under an activated TME. In proof-of-concept studies, the treatment of G-T/C-L with NIR illumination showed a significant improvement in anticancer efficacy bothin vitroandin vivobut without conventional photothermal therapy-associated side effects. This study proposes photothermal-triggered technology to realize controlled drug release, enriching the application with combinational STS and celastrol in anti-breast cancer therapy. |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; THERMOSENSITIVE LIPOSOMES ; NANOPARTICLES ; FIBROBLASTS ; DOXORUBICIN ; PACLITAXEL |
| 资助项目 | National Natural Science Foundation of China[81873017] ; Key Medical Youth Talent Project of Jiangsu Province[QNRC2016631] ; Six Talent Peak Project of Jiangsu Province[YY-028-2019] ; Key Research Project of Jiangsu Provincial Academy of Traditional Chinese Medicine[BM2018024-2019002] ; Jiangsu Provincial Government Scholarship for Overseas Study |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000548702000011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; Key Medical Youth Talent Project of Jiangsu Province ; Six Talent Peak Project of Jiangsu Province ; Key Research Project of Jiangsu Provincial Academy of Traditional Chinese Medicine ; Jiangsu Provincial Government Scholarship for Overseas Study |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/102953]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Yan; Qu, Ding |
| 作者单位 | 1.Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing 210028, Peoples R China 2.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Peoples R China 3.Chinese Acad Sci, Canc Hosp, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Yue,Liu, Tingting,Guo, Mengfei,et al. Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy[J]. BIOMATERIALS SCIENCE,2020,8. |
| APA | Qin, Yue.,Liu, Tingting.,Guo, Mengfei.,Liu, Yuping.,Liu, Congyan.,...&Qu, Ding.(2020).Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy.BIOMATERIALS SCIENCE,8. |
| MLA | Qin, Yue,et al."Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy".BIOMATERIALS SCIENCE 8(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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