Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism
文献类型：期刊论文
| 作者 | Cui, Shujun1,2; Chen, Guodong1; Yu, K. N.3,4; Cheng, Cheng5; Han, Wei1,6,7
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| 刊名 | JOURNAL OF PHYSICS D-APPLIED PHYSICS
 |
| 出版日期 | 2020-09-16 |
| 卷号 | 53 |
| 关键词 | non-thermal plasma metformin AMP-activated protein kinase energy metabolism |
| ISSN号 | 0022-3727 |
| DOI | 10.1088/1361-6463/ab938a |
| 通讯作者 | Han, Wei(hanw@hfcas.ac.cn) |
| 英文摘要 | Non-thermal plasma (NTP) has a selective killing effect on a variety of cancer cellsin vivoandin vitro, and is considered a potential tumor therapy. In this study, we found that metformin, which has shown promising antitumor effects in previous studies, with NTP synergistically increased cell death including apoptosis in colon cancer cell lines via reducing mitochondrial oxidative phosphorylation and intracellular adenosine triphosphate exhausting cellular energy, mediated through activation of AMP-activated protein kinase (AMPK). Reactive oxygen species was revealed to modulate the activation of AMPK after NTP exposure. Considering the safety and wide clinical use of metformin, the combination of metformin and NTP showed great potential in cancer therapy. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; CANCER PREVENTION ; COMPLEX 1 ; APOPTOSIS ; ROS ; INDUCTION |
| 资助项目 | National Key R&D Program of China[2019YFC0119000] ; Chinese National Natural Science Foundation[81573093] ; Chinese National Natural Science Foundation[U1632145] ; CASHIPS Director's Fund[YZJJ 2018QN19] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong[IRF/0024] |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000549872400001 |
| 出版者 | IOP PUBLISHING LTD |
| 资助机构 | National Key R&D Program of China ; Chinese National Natural Science Foundation ; CASHIPS Director's Fund ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/102961]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Han, Wei |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 3.City Univ Hong Kong, Dept Phys, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China 4.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Plasma Sci & Technol, Hefei Inst Phys Sci, Hefei, Anhui, Peoples R China 6.Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou, Jiangsu, Peoples R China 7.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Shujun,Chen, Guodong,Yu, K. N.,et al. Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS,2020,53. |
| APA | Cui, Shujun,Chen, Guodong,Yu, K. N.,Cheng, Cheng,&Han, Wei.(2020).Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism.JOURNAL OF PHYSICS D-APPLIED PHYSICS,53. |
| MLA | Cui, Shujun,et al."Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism".JOURNAL OF PHYSICS D-APPLIED PHYSICS 53(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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