CRISPR/Cas9-related technologies in liver diseases: from feasibility to future diversity
文献类型：期刊论文
| 作者 | Xu, Ta2,3; Li, Li4,5,6,7; Liu, Yu-chen8; Cao, Wei9; Chen, Jia-si2,3; Hu, Shuang2,3; Liu, Ying10,11 ; Li, Liang-yun2,3; Zhou, Hong2,3,12; Meng, Xiao-ming2,3
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
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| 出版日期 | 2020 |
| 卷号 | 16 |
| 关键词 | CRISPR/Cas9 viral hepatitis hepatocellular carcinoma (HCC) clinical research |
| ISSN号 | 1449-2288 |
| DOI | 10.7150/ijbs.33481 |
| 通讯作者 | Li, Jun(lj@ahmu.edu.cn) ; Zhou, Huan(zhouhuanbest@163.com) |
| 英文摘要 | Liver diseases are one of the leading causes of mortality in the world, mainly caused by different etiological agents, alcohol consumption, viruses, drug intoxication, and malnutrition. The maturation of gene therapy has heralded new avenues for developing effective interventions for these diseases. Derived from a remarkable microbial defense system, clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins 9 system (CRISPR/Cas9 system) is driving innovative applications from basic biology to biotechnology and medicine. Recently, the mutagenic function of CRISPR/Cas9 system has been widely adopted for genome and disease research. In this review, we describe the development and applications of CRISPR/Cas9 system on liver diseases for research or translational applications, while highlighting challenges as well as future avenues for innovation. |
| WOS关键词 | HEPATITIS-B ; POOR-PROGNOSIS ; IN-VIVO ; CRISPR-CAS9 ; RNA ; GENE ; SYSTEM ; CLASSIFICATION ; IDENTIFICATION ; PROLIFERATION |
| 资助项目 | National Natural Science Foundation of China[81700522] ; National Natural Science Foundation of China[81602344] ; National Natural Science Foundation of China[81773257] ; Anhui medical university[0601067101] ; Anhui Provincial Natural Science Foundation[1704a0802161] ; Soft science project of Anhui provincial science and technology department[1607a0202062] ; Natural Science Foundation of Anhui Province[1808085MH235] ; Natural Science Foundation of Guangdong[2018B030306023] ; Key Special Project of Translational Medicine of Bengbu Medical University[BYTM2019021] ; General Medicine Clinical Scientific Research Project of Anhui Provincial Health Committee[2016QK090] ; training objects of excellent young teachers in the 512 talent plan of Bengbu Medical College |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000548244800003 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | National Natural Science Foundation of China ; Anhui medical university ; Anhui Provincial Natural Science Foundation ; Soft science project of Anhui provincial science and technology department ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Guangdong ; Key Special Project of Translational Medicine of Bengbu Medical University ; General Medicine Clinical Scientific Research Project of Anhui Provincial Health Committee ; training objects of excellent young teachers in the 512 talent plan of Bengbu Medical College |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/102969]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Li, Jun; Zhou, Huan |
| 作者单位 | 1.Bengbu Med Coll, Affiliated Hosp 1, Natl Drug Clin Trial Inst, Bengbu, Anhui, Peoples R China 2.Anhui Med Univ, Sch Pharm, Inflammat & Immune Mediated Dis Lab Anhui Prov, Anhui Inst Innovat Drugs, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China 3.Anhui Med Univ, Inst Liver Dis, Hefei 230032, Peoples R China 4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Pathol & Pathophysiol, Hangzhou, Peoples R China 5.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Bone Marrow Transplantat Ctr, Hangzhou, Peoples R China 6.Zhejiang Univ, Inst Hematol, Hangzhou, Peoples R China 7.Zhejiang Engn Lab Stem Cell & Immunotherapy, Hangzhou, Peoples R China 8.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Key Lab Med Reprogramming Technol, Shenzhen 518039, Peoples R China 9.Shenzhen Qianhai Icecold IT Co Ltd, Shenzhen, Peoples R China 10.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ta,Li, Li,Liu, Yu-chen,et al. CRISPR/Cas9-related technologies in liver diseases: from feasibility to future diversity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2020,16. |
| APA | Xu, Ta.,Li, Li.,Liu, Yu-chen.,Cao, Wei.,Chen, Jia-si.,...&Zhou, Huan.(2020).CRISPR/Cas9-related technologies in liver diseases: from feasibility to future diversity.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,16. |
| MLA | Xu, Ta,et al."CRISPR/Cas9-related technologies in liver diseases: from feasibility to future diversity".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 16(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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