Different Risk Target Volumes for Nasopharyngeal Carcinoma Treated with Simultaneous Integrated Boost Intensity-Modulated Radiotherapy
文献类型：期刊论文
| 作者 | Wang, Fangzheng2,3,4,5; Jiang, Chuner1,2,6; Wang, Lei2,3,4,5; Yan, Fengqin2,3,4,5; Piao, Yongfeng2,3,4,5; Ye, Zhimin2,3,4,5; Xu, Min1,2,6; Liu, Jiping1,2,6; Fu, Zhenfu2,3,4,5; Jiang, Yangming7 |
| 刊名 | JOURNAL OF CANCER
 |
| 出版日期 | 2020 |
| 卷号 | 11 |
| 关键词 | nasopharyngeal carcinoma IMRT target volume dose long-term survival |
| ISSN号 | 1837-9664 |
| DOI | 10.7150/jca.45767 |
| 通讯作者 | Wang, Fangzheng(wangfz76@126.com) ; Fu, Zhenfu(fzf1000@163.com) |
| 英文摘要 | Background and Objectives: Although intensity-modulated radiotherapy (IMRT) provides promising survival advantages and fewer late complications in patients with nasopharyngeal cancer (NPC), appropriated target volumes and prescribed doses are still being explored. This study aimed to propose different risk target volumes and corresponding prescribed doses in our center and to evaluate the physical basis and efficacy of this protocol based on the long-term survival of NPC patients. Methods and Materials: We retrospectively assessed patients with histology-proven non-metastatic NPC treated with definitive IMRT using our protocol of different risk target volumes and corresponding prescribed doses based on the orderly stepwise pattern of tumor spread. We described the delineation for different risk target volumes and the design of IMRT planning for an NPC case. Additionally, we compared the dosimetric distributions between the China protocol and our protocol through two NPC cases. The patterns of failure and locoregional control were the primary endpoints. All survival outcomes were calculated using the Kaplan-Meier method. Results: From January 2013 to December 2014, a total of 335 patients were treated; the median follow-up for patients who survived was 70 months. All patients completed IMRT using our protocol. Twenty-five patients developed locoregional recurrence, and all recurrences occurred within the high-dose target volumes. The rates of locoregional recurrence-free survival, distant metastasis-free survival, progression-free survival, and overall survival at 5 years were 92.2%, 92.1%, 85.9%, and 86.3%, respectively. The biological effective doses of the prescribed doses in our protocol were similar to those of the China and 0615 protocols. Moreover, our protocol offered a reduction in D1 and D2 in the primary gross tumor volume (GTV), while V30 and V40 in normal tissues were lower. Conclusion: Our protocol of different risk target volume delineations and corresponding prescribed doses based on the stepwise pattern of tumor spread resulted in favorable locoregional control with no relapse outside the GTV. |
| WOS关键词 | RADIATION-THERAPY ; EXTENSION PATTERNS ; CHEMOTHERAPY ; SURVIVAL ; EFFICACY ; IMPACT ; HEAD ; CTV |
| 资助项目 | Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2013KYB033] ; Medical and Health Science and Technology Program of Zhejiang Province[2009B026] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; Medical and Health Science and Technology Program of Zhejiang Province[2004B014] ; National Natural Science Foundation of China[81502647] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000549096300027 |
| 出版者 | IVYSPRING INT PUBL |
| 资助机构 | Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/102971]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Fangzheng; Fu, Zhenfu |
| 作者单位 | 1.Zhejiang Canc Hosp, Dept Breast Tumor Surg, Hangzhou 310022, Zhejiang, Peoples R China 2.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 4.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou 310022, Zhejiang, Peoples R China 5.Key Lab Radiat Oncol Zhejiang Prov, Hangzhou 310022, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, Dept Breast Tumor Surg, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 7.Chinese Acad Sci, Dept Digital Earth, Inst Remote Sensing & Digital Earth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Fangzheng,Jiang, Chuner,Wang, Lei,et al. Different Risk Target Volumes for Nasopharyngeal Carcinoma Treated with Simultaneous Integrated Boost Intensity-Modulated Radiotherapy[J]. JOURNAL OF CANCER,2020,11. |
| APA | Wang, Fangzheng.,Jiang, Chuner.,Wang, Lei.,Yan, Fengqin.,Piao, Yongfeng.,...&Jiang, Yangming.(2020).Different Risk Target Volumes for Nasopharyngeal Carcinoma Treated with Simultaneous Integrated Boost Intensity-Modulated Radiotherapy.JOURNAL OF CANCER,11. |
| MLA | Wang, Fangzheng,et al."Different Risk Target Volumes for Nasopharyngeal Carcinoma Treated with Simultaneous Integrated Boost Intensity-Modulated Radiotherapy".JOURNAL OF CANCER 11(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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