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Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma

文献类型：期刊论文

作者Ye, Liuqing1,2,3,4; Zhou, Xi2; Lu, Jie2; Wang, Yanzhong2; Xie, Xinyou2,5; Zhang, Jun2,5
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
出版日期2020-07-01
卷号34
关键词calcitonin carcinoembryonic antigen lymph node metastasis medullary thyroid carcinoma neuron-specific enolase
ISSN号0887-8013
DOI10.1002/jcla.23278
通讯作者Xie, Xinyou(scottxie@mail.hz.zj.cn) ; Zhang, Jun(jameszhang2000@zju.edu.cn)
英文摘要Background This study aimed to investigate the clinical application of combined detection of serum calcitonin (Ctn), carcinoembryonic antigen (CEA), and neuron-specific enolase (NSE) in predicting lateral lymph node metastasis (LLNM) in medullary thyroid carcinoma (MTC). Methods Seventy-four consecutive patients with MTC were enrolled. The relationship between serum Ctn, CEA, and NSE and LLNM was retrospectively analyzed by univariate analysis and logistic regression analysis. Furthermore, the clinical application of serum Ctn, CEA, and NSE combined detection in prediction of LLNM in MTC was also evaluated. Results The rate of LLNM in this study was 48.64% (36/74).The expression levels of serum Ctn, CEA, and NSE in MTC with LLNM were significantly higher than those without LLNM (allP < .01). The area under the curve (AUC) predicted by serum Ctn, CEA, and NSE for LLNM in MTC patients was 0.867, 0.831, and 0.726, respectively, and the AUC of serum Ctn, CEA, and NSE combined detection was up to 0.890, higher than using a single biomarker. The sensitivity and specificity of serum Ctn, CEA, and NSE combined detection in prediction of LLNM were 88.89% and 81.57%, respectively. Conclusions The concentrations of serum Ctn, CEA, and NSE are closely related to LLNM in MTC, and the combined detection of all three biomarkers has a higher clinical value in the evaluation of MTC patients with LLNM. With more perspective study in the future, it would be an indicator of influencing personalized surgical strategy for different MTC patients.
WOS关键词FREE SURVIVAL ; BIOMARKER ; MANAGEMENT
WOS研究方向Medical Laboratory Technology
语种英语
WOS记录号WOS:000551044400042
出版者WILEY
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/102979]  
专题中国科学院合肥物质科学研究院
通讯作者Xie, Xinyou; Zhang, Jun
作者单位1.Zhejiang Canc Hosp, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Clin Lab, Hangzhou 310016, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China
5.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Biomed Res Ctr, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Liuqing,Zhou, Xi,Lu, Jie,et al. Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2020,34.
APA Ye, Liuqing,Zhou, Xi,Lu, Jie,Wang, Yanzhong,Xie, Xinyou,&Zhang, Jun.(2020).Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma.JOURNAL OF CLINICAL LABORATORY ANALYSIS,34.
MLA Ye, Liuqing,et al."Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma".JOURNAL OF CLINICAL LABORATORY ANALYSIS 34(2020).

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来源：合肥物质科学研究院

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