中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

文献类型：期刊论文

作者Wang, Weiyi3; Yang, Jing5; Liao, Yan-Yan2; Cheng, Gang5; Chen, Jing5; Cheng, Xiang-Dong1,4; Qin, Jiang-Jiang1,4,5; Shao, Zongze3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2020-04-24
卷号83
ISSN号0163-3864
DOI10.1021/acs.jnatprod.9b01165
通讯作者Wang, Weiyi(wywang@tio.org.cn) ; Cheng, Xiang-Dong(chengxd516@126.com) ; Qin, Jiang-Jiang(jqin@zcmu.edu.cn)
英文摘要Eight new nitrogenated azaphilones (1-8) and two known compounds (chaetoviridin A and chaetoviridin E, 9, 10) were isolated from the culture of the deep-sea-derived fungus Chaetomium globosum MP4-S01-7. The absolute configurations of new compounds were elucidated by HSQC-HECADE NMR data, J-based configuration analysis, and modified Mosher's method and finally verified by comparison of recorded and computed NMR chemical shifts from quantum chemical calculations coupled with a statistical procedure (DP4+). All of the compounds were evaluated for their in vitro cytotoxicities against the gastric cancer cell lines MGC803 and AGS, and most of them showed significant inhibition on cancer cell viability at 10 mu M. Among them, compounds 1, 2, and 5 exerted the most potent cytotoxic activities, with IC50 values less than 1 mu M. Further studies showed that compound 2 inhibited cell cycle progression, and both compounds 1 and 2 induced apoptosis of gastric cancer cells in a concentration-dependent manner.
WOS关键词ABSOLUTE-CONFIGURATION ; PIGMENTS
资助项目Natural Science Foundation of Fujian Province[2018J01064] ; COMRA program[DY135-B2-01] ; COMRA program[DY135-B2-05] ; Foundation of Third Institute of Oceanography SOA[2018021] ; Foundation of Third Institute of Oceanography SOA[2017001] ; National Natural Science Foundation of China[81903842] ; National Natural Science Foundation of China[81573953] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2020ZZ005] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2016ZZ012] ; Zhejiang Chinese Medical University[111100E014] ; Zhejiang Provincial Science and Technology Projects[2019C03049] ; Medical Science and Technology Project of Zhejiang Province[WKJ-ZJ-1728] ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province[2018ZY006]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000529168400036
出版者AMER CHEMICAL SOC
资助机构Natural Science Foundation of Fujian Province ; COMRA program ; Foundation of Third Institute of Oceanography SOA ; National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan ; Zhejiang Chinese Medical University ; Zhejiang Provincial Science and Technology Projects ; Medical Science and Technology Project of Zhejiang Province ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103007]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Weiyi; Cheng, Xiang-Dong; Qin, Jiang-Jiang
作者单位1.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou 310022, Peoples R China
2.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China
3.Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen 361005, Peoples R China
4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Peoples R China
5.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Weiyi,Yang, Jing,Liao, Yan-Yan,et al. Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7[J]. JOURNAL OF NATURAL PRODUCTS,2020,83.
APA Wang, Weiyi.,Yang, Jing.,Liao, Yan-Yan.,Cheng, Gang.,Chen, Jing.,...&Shao, Zongze.(2020).Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7.JOURNAL OF NATURAL PRODUCTS,83.
MLA Wang, Weiyi,et al."Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7".JOURNAL OF NATURAL PRODUCTS 83(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。