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In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging

文献类型：期刊论文

作者Qian, Junchao1,2; Yu, Xiang1; Li, Bingbing1; Fei, Zhenle1; Huang, Xiang1; Luo, Peng1; Zhang, Liwei1; Zhang, Zhiming1; Lou, Jianjun1; Wang, Hongzhi1,2
刊名CURRENT MEDICAL IMAGING
出版日期2020
卷号16
关键词Oxygen level brain tumor oxygen-enhanced magnetic resonance imaging fractionated radiotherapy brain metastasis radiotherapy
ISSN号1573-4056
DOI10.2174/1573405614666180925144814
通讯作者Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Wang, Hongzhi(wanghz@hfcas.ac.cn)
英文摘要Background: It was known that the response of tumor cells to radiation is closely related to tissue oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor cells. Non-invasive mapping of tissue oxygen level may hold great importance in clinic. Objective: The aim of this study is to evaluate the role of oxygen-enhanced MR imaging in the detection of tissue oxygen levels between fractionated radiotherapy. Methods: A cohort of 10 patients with brain metastasis was recruited. Quantitative oxygen enhanced MR imaging was performed prior to, 30 minutes and 22 hours after first fractionated radiotherapy. Results: The Delta R-1 (the difference of longitudinal relaxivity between 100% oxygen breathing and air breathing) increased in the ipsilateral tumor site and normal tissue by 242% and 152%, respectively, 30 minutes after first fractionated radiation compared to pre-radiation levels. Significant recovery of Delta R-1 in the contralateral normal tissue (p < 0.05) was observed 22 hours compared to 30 minutes after radiation levels. Conclusion: R-1-based oxygen-enhanced MR imaging may provide a sensitive endogenous marker for oxygen changes in the brain tissue between fractionated radiotherapy.
WOS关键词RADIATION-THERAPY ; RELAXATION-TIMES ; INHALATION ; HYPOXIA ; RELEVANCE ; CANCER ; PO(2)
资助项目National Natural Science Foundation of China[81201068]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000537883000007
出版者BENTHAM SCIENCE PUBL LTD
资助机构National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103117]  
专题中国科学院合肥物质科学研究院
通讯作者Qian, Junchao; Wang, Hongzhi
作者单位1.Chinese Acad Sci, Hefei Canc Hosp, Hefei Inst Phys Sci, 350 Shushanhu Rd, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Qian, Junchao,Yu, Xiang,Li, Bingbing,et al. In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging[J]. CURRENT MEDICAL IMAGING,2020,16.
APA Qian, Junchao.,Yu, Xiang.,Li, Bingbing.,Fei, Zhenle.,Huang, Xiang.,...&Wang, Hongzhi.(2020).In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging.CURRENT MEDICAL IMAGING,16.
MLA Qian, Junchao,et al."In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging".CURRENT MEDICAL IMAGING 16(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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