Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers
文献类型：期刊论文
| 作者 | Wen, Pengbo1,2,3; Gao, Yang1,2,3; Chen, Bin1,2,3 ; Qi, Xiaojing1,2,3; Hu, Guanshuo1,2,3; Xu, An1,2; Xia, Junfeng4; Wu, Lijun1,2; Lu, Huayi5; Zhao, Guoping1,2
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| 刊名 | CANCERS
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 12 |
| 关键词 | pan-cancer radiotherapy immune infiltration prognosis |
| DOI | 10.3390/cancers12040957 |
| 通讯作者 | Lu, Huayi(Lhy510@jlu.edu.cn) ; Zhao, Guoping(gpz@ipp.ac.cn) |
| 英文摘要 | Response to radiotherapy (RT) in cancers varies widely among patients. Therefore, it is very important to predict who will benefit from RT before clinical treatment. Consideration of the immune tumor microenvironment (TME) could provide novel insight into tumor treatment options. In this study, we investigated the link between immune infiltration status and clinical RT outcome in order to identify certain leukocyte subsets that could potentially influence the clinical RT benefit across cancers. By integrally analyzing the TCGA data across seven cancers, we identified complex associations between immune infiltration and patients RT outcomes. Besides, immune cells showed large differences in their populations in various cancers, and the most abundant cells were resting memory CD4 T cells. Additionally, the proportion of activated CD4 memory T cells and activated mast cells, albeit at low number, were closely related to RT overall survival in multiple cancers. Furthermore, a prognostic model for RT outcomes was established with good performance based on the immune infiltration status. Summarized, immune infiltration was found to be of significant clinical relevance to RT outcomes. These findings may help to shed light on the impact of tumor-associated immune cell infiltration on cancer RT outcomes, and identify biomarkers and therapeutic targets. |
| WOS关键词 | TUMOR MICROENVIRONMENT ; RADIATION ONCOLOGY ; SIGNATURE ; COMBINATION ; VALIDATION ; THERAPY ; CELLS ; ERA |
| 资助项目 | National Natural Science Foundation of China[31870845] ; National Natural Science Foundation of China[11835014] ; National Natural Science Foundation of China[31601124] ; CAS Pioneer Hundred Talents Program |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000535587400185 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103149]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lu, Huayi; Zhao, Guoping |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 2.Anhui Prov Key Lab Environm Toxicol & Pollut Cont, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China 4.Anhui Univ, Sch Comp Sci & Technol, Inst Phys Sci & Informat Technol, Hefei 230039, Peoples R China 5.Univ Sci & Technol China, Div Life Sci & Med, Dept Ophthalmol & Visual Sci, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Pengbo,Gao, Yang,Chen, Bin,et al. Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers[J]. CANCERS,2020,12. |
| APA | Wen, Pengbo.,Gao, Yang.,Chen, Bin.,Qi, Xiaojing.,Hu, Guanshuo.,...&Zhao, Guoping.(2020).Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers.CANCERS,12. |
| MLA | Wen, Pengbo,et al."Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers".CANCERS 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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