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Progress on treatment of MET signaling pathway in non-small cell lung cancer

文献类型：期刊论文

作者Yu, Xiaoqing1,2,3; Yu, Sizhe2,3; Fan, Yun1,2,3
刊名INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
出版日期2020-05-21
关键词MET Dysregulation Overexpression Amplification Non-small cell lung cancer
ISSN号1341-9625
DOI10.1007/s10147-020-01702-0
通讯作者Fan, Yun(fanyun_zicc@163.com)
英文摘要MET activation includes gene mutation, amplification, and protein overexpression. Clinical evidence suggests that MET activation is both a primary oncogenic driver in lung cancer, and a secondary driver after acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Several small molecule TKIs have already shown to be effective in the MET pathway. However, the activation form and the diagnostic criteria of MET oncogene are still controversial, especially in patients resistant to EGFR TKIs or ALK TKIs. With the development of new MET inhibitors, a quantity of emerging trials has focused on the mechanism of acquired resistance to MET TKIs and therapeutic strategies after resistance.
WOS关键词TYROSINE KINASE INHIBITORS ; TIVANTINIB ARQ 197 ; EGFR-MUTANT NSCLC ; EXON 14 MUTATIONS ; ACQUIRED-RESISTANCE ; PLUS ERLOTINIB ; DOUBLE-BLIND ; PHASE-II ; AMPLIFICATION ; GROWTH
WOS研究方向Oncology
语种英语
WOS记录号WOS:000534831100001
出版者SPRINGER JAPAN KK
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103175]  
专题中国科学院合肥物质科学研究院
通讯作者Fan, Yun
作者单位1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China
2.Univ Chinese Acad Sci, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China
3.Zhejiang Canc Hosp, Dept Med Oncol, 1 Banshandong Rd, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Xiaoqing,Yu, Sizhe,Fan, Yun. Progress on treatment of MET signaling pathway in non-small cell lung cancer[J]. INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY,2020.
APA Yu, Xiaoqing,Yu, Sizhe,&Fan, Yun.(2020).Progress on treatment of MET signaling pathway in non-small cell lung cancer.INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY.
MLA Yu, Xiaoqing,et al."Progress on treatment of MET signaling pathway in non-small cell lung cancer".INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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