Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth
文献类型：期刊论文
| 作者 | Chen, Yongyi1,2,3; Gong, Wangang1,2,3; Zhou, Yun1,2,3; Fan, Runping1,2,3; Wu, Yuchen1,2,3; Pei, Wangwei1,2,3; Sun, Sufang1,2,3; Xu, Xiaohong1,2,3; Jiang, Huifen1,2,3 |
| 刊名 | TRANSLATIONAL CANCER RESEARCH
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 9 |
| ISSN号 | 2218-676X |
| 关键词 | Gastric cancer (GC) metformin miR-107 bioinformatics analysis survival outcomes proliferation |
| DOI | 10.21037/tcr.2020.03.25 |
| 通讯作者 | Jiang, Huifen(jianghuifentougao@163.com) |
| 英文摘要 | Gastric cancer (GC) is one of the most common malignant neoplasms and is the third leading cause of cancer-related death around the world. Metformin has been well reported to have an inhibitory effect on the growth of various cancers by regulating the expression of microRNAs (miRNAs). However, the specific miRNA(s) regulated by metformin in GC have not been identified. In this study, real-time reverse transcription polymerase chain reaction (RT-PCR) analysis in vitro indicated that miR-107 expression was up-regulated in metformin-treated SGC-7901 cells compared with untreated SGC-7901 and MGC803 cells. Amplification of miR-107 expression further reduced cell proliferation in metformin-treated GC cells. A bioinformatics analysis showed that mitogen-activated protein kinase 8 (MAPK8) was the common target of metformin and miR-107. MAPK8 expression is associated with immune cell infiltration in GC as well as overall GC patient survival. Our study demonstrates that rniR-107 enhances the anti-cancer effects of metformin in GC tissues, which offers a novel strategy for the treatment of GC. |
| WOS关键词 | IN-VITRO ; SENSITIVITY ; MICRORNAS ; CELLS ; DRUG |
| 资助项目 | Medical and Health Science and Technology Project of Zhejiang Province[2015KYB060] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | AME PUBL CO |
| WOS记录号 | WOS:000530914200079 |
| 资助机构 | Medical and Health Science and Technology Project of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103279]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Jiang, Huifen |
| 作者单位 | 1.Zhejiang Canc Hosp, Dept Clin Lab, 1 East Banshan Rd, Hangzhou 310022, Peoples R China 2.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yongyi,Gong, Wangang,Zhou, Yun,et al. Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth[J]. TRANSLATIONAL CANCER RESEARCH,2020,9. |
| APA | Chen, Yongyi.,Gong, Wangang.,Zhou, Yun.,Fan, Runping.,Wu, Yuchen.,...&Jiang, Huifen.(2020).Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth.TRANSLATIONAL CANCER RESEARCH,9. |
| MLA | Chen, Yongyi,et al."Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth".TRANSLATIONAL CANCER RESEARCH 9(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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