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Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors

文献类型：期刊论文

作者Zhang, Da1,2; Zheng, Youshi1; Lin, Ziguo1; Liu, Xiaolong1; Li, Juan2,3,4; Yang, Huanghao2; Tan, Weihong3,4
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2020-05-12
关键词aptamers immunology natural killer cells PD1 PDL1 checkpoint blockade solid tumors
ISSN号1433-7851
DOI10.1002/anie.202002145
通讯作者Li, Juan(lijuan@fzu.edu.cn) ; Yang, Huanghao(hhyang@fzu.edu.cn)
英文摘要Herein, we propose an aptamer-equipping strategy to generate specific, universal and permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. NK cells were chemically equipped with TLS11a aptamer targeting HepG2 cells and PDL1-specific aptamer without genetic alteration. The dual aptamer-equipped NK cells exhibited high specificity to tumor cells, resulting in higher cytokine secretion and apoptosis/necrosis compared to parental or single aptamer-equipped NK cells. Interestingly, dual aptamer-equipped NK cells induced remarkable upregulation of PDL1 expression in HepG2 cells, enhancing checkpoint blockade. Furthermore, in vivo intravital imaging demonstrated high infiltration of aptamer-equipped NK cells into deep tumor region, leading to enhanced therapeutic efficacy in solid tumors. This work offers a straightforward chemical strategy to equip NK cells with aptamers, holding considerable potential for enhanced adoptive immunotherapy in solid tumors.
WOS关键词CANCER-IMMUNOTHERAPY ; TRANSFER THERAPY ; DNA APTAMER
资助项目Natural Science Foundation of China[91959102] ; Natural Science Foundation of China[21635002] ; Natural Science Foundation of China[61805041] ; Natural Science Foundation of Fujian Province of China[2017J06004] ; Shanghai Rising-Star Program[19QA1405400] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT15R11]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000531691900001
出版者WILEY-V C H VERLAG GMBH
资助机构Natural Science Foundation of China ; Natural Science Foundation of Fujian Province of China ; Shanghai Rising-Star Program ; Program for Changjiang Scholars and Innovative Research Team in University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103281]  
专题中国科学院合肥物质科学研究院
通讯作者Li, Juan; Yang, Huanghao
作者单位1.Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
2.Fuzhou Univ, MOE Key Lab Analyt Sci Food Safety & Biol, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Coll Chem,State Key Lab Photocatalysis Energy & E, Fuzhou 350116, Peoples R China
3.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou 310022, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Da,Zheng, Youshi,Lin, Ziguo,et al. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020.
APA Zhang, Da.,Zheng, Youshi.,Lin, Ziguo.,Liu, Xiaolong.,Li, Juan.,...&Tan, Weihong.(2020).Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Zhang, Da,et al."Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020).

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来源：合肥物质科学研究院

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