Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging
文献类型：期刊论文
| 作者 | Qi, Meiyuan2; Pan, Hui2; Shen, Hongdou2; Xia, Xianmeng2; Wu, Chu2; Han, Xiaoke2; He, Xingyue2; Tong, Wei1 ; Wang, Xia2; Wang, Qigang2
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-05-08 |
| 关键词 | enzymes fluorescence imaging agents iron nanogels |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202002331 |
| 通讯作者 | Wang, Xia(15174@tongji.edu.cn) ; Wang, Qigang(wangqg66@tongji.edu.cn) |
| 英文摘要 | The design of enzyme mimics from stable and nonprotein systems is especially attractive for applications in highly specific cancer diagnosis and treatment, and it has become an emerging field in recent years. Herein, metal crosslinked polymeric nanogels (MPGs) were prepared using Fe-II ion coordinated biocompatible acryloyl-lysine polymer brushes obtained from an enzyme-catalyzed atomic transfer radical polymerization (ATRPase) method. The monoatomic and highly dispersed Fe ions in the MPGs serve as efficient crosslinkers of the gel network, and also as active centers of multienzyme mimics of superoxide dismutase (SOD) and peroxidase (POD). The catalytic activities were compared to those of conventional Fe-based nanozymes. Studies on both cells and animals verify that efficient reactive oxygen species (ROS) responsive biofluorescence imaging can be successfully realized using the MPGs. |
| WOS关键词 | ORGANIC-FRAMEWORK NANOSHEETS ; HYBRID NANOGELS ; BINDING ; NANOPARTICLES ; DESIGN ; GROWTH ; ENZYME ; ACIDS ; OXIDE ; IRON |
| 资助项目 | National Natural Science Foundation of China[51773155] ; National Natural Science Foundation of China[51873156] ; National Key Research and Development Program[2016YFA0100800] ; National Key Research and Development Program[2018YFC1803100] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000530871300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103293]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Xia; Wang, Qigang |
| 作者单位 | 1.Chinese Acad Sci, High Field Magnet Lab, 350 Shushanhu Rd, Hefei 230031, Peoples R China 2.Tongji Univ, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Meiyuan,Pan, Hui,Shen, Hongdou,et al. Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020. |
| APA | Qi, Meiyuan.,Pan, Hui.,Shen, Hongdou.,Xia, Xianmeng.,Wu, Chu.,...&Wang, Qigang.(2020).Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. |
| MLA | Qi, Meiyuan,et al."Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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