A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications
文献类型：期刊论文
| 作者 | Lin, Jixing3,4; Tong, Xian3,4; Shi, Zimu1 ; Zhang, Dechuang4; Zhang, Lishu5; Wang, Kun3; Wei, Aiping3; Jin, Lufan3; Lin, Jianguo4; Li, Yuncang2
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| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 106 |
| ISSN号 | 1742-7061 |
| 关键词 | Antibacterial ability Biodegradable metal Friction and wear In vitro biocompatibility Zn alloy |
| DOI | 10.1016/j.actbio.2020.02.017 |
| 通讯作者 | Wen, Cuie(cuie.wen@rmit.edu.au) |
| 英文摘要 | Zinc (Zn) alloys are receiving increasing attention in the field of biodegradable implant materials due to their unique combination of suitable biodegradability and good biological functionalities. However, the currently existing industrial Zn alloys are not necessarily biocompatible, nor sufficiently mechanically strong and wear-resistant. In this study, a Zn-1Cu-0.1Ti alloy is developed with enhanced mechanical strength, corrosion wear property, biocompatibility, and antibacterial ability for biodegradable implant material applications. HR and HR + CR were performed on the as-cast alloy and its microstructure, mechanical properties, frictional and wear behaviors, corrosion resistance, in vitro cytocompatibility, and antibacterial ability were systematically assessed. The microstructures of the Zn-1Cu-0.1Ti alloy after different deformation conditions included a eta-Zn phase, a epsilon-CuZn5 phase, and an intermetallic phase of TiZn16. The HR+CR sample of Zn-1Cu-0.1Ti exhibited a yield strength of 204.2 MPa, an ultimate tensile strength of 249.9 MPa, and an elongation of 75.2%; significantly higher than those of the HR alloy and the AC alloy. The degradation rate in Hanks' solution was 0.029 mm/y for the AC alloy, 0.032 mm/y for the HR+CR alloy, and 0.034 mm/y for the HR alloy. The HR Zn-1Cu-0.1Ti alloy showed the best wear resistance, followed by the AC alloy and the alloy after HR + CR. The extract of the AC Zn-1Cu-0.1Ti alloy showed over 80% cell viability with MC3T3-E1 pre-osteoblast and MG-63 osteosarcoma cells at a concentration of <= 25%. The as-cast Zn-1Cu-0.1Ti alloy showed good blood compatibility and antibacterial ability. Statement of Significance This work repots a Zn-1Cu-0.1Ti alloy with enhanced mechanical strength, corrosion wear property, biocompatibility, and antibacterial ability for biodegradable implant applications. Our findings showed that Zn-1Cu-0.1Ti after hot-rolling plus cold-rolling exhibited a yield strength of 204.2 MPa, an ultimate tensile strength of 249.9 MPa, an elongation of 75.2%, and a degradation rate of 0.032 mm/y in Hanks' Solution. The hot-rolled Zn-1Cu-0.1Ti showed the best wear resistance. The extract of the as-cast alloy at a concentration of <= 25% showed over 80% cell viability with MC3T3-E1 and MG-63 cells. The Zn-1Cu-0.1Ti alloy showed good hemocompatibility and antibacterial ability. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | IN-VITRO DEGRADATION ; MICRO-ABRASION-CORROSION ; TRACE-ELEMENTS ; BINARY-ALLOYS ; WEAR BEHAVIOR ; MAGNESIUM ; ZINC ; TITANIUM ; SURFACE ; METAL |
| 资助项目 | Wenzhou Science and Technology Bureau[G20180027] ; Wenzhou Science and Technology Bureau[2018ZG008] ; Australian Research Council (ARC)[DP170102557] ; Australian Research Council (ARC)[FT160100252] ; Hunan Provincial Natural Science Foundation of China[2016JC2005] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000527368300033 |
| 资助机构 | Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) ; Hunan Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103363]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wen, Cuie |
| 作者单位 | 1.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China 2.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia 3.Zhejiang Ind & Trade Vocat Coll, Dept Mat Engn, Wenzhou 325003, Peoples R China 4.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 5.Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Inst Adv Mat Nanobio Applicat, Wenzhou 325027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Jixing,Tong, Xian,Shi, Zimu,et al. A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications[J]. ACTA BIOMATERIALIA,2020,106. |
| APA | Lin, Jixing.,Tong, Xian.,Shi, Zimu.,Zhang, Dechuang.,Zhang, Lishu.,...&Wen, Cuie.(2020).A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications.ACTA BIOMATERIALIA,106. |
| MLA | Lin, Jixing,et al."A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications".ACTA BIOMATERIALIA 106(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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