Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry
文献类型：期刊论文
| 作者 | Zhou, Wenzhao1,2; Huang, Chaoqun2 ; Zou, Xue2; Lu, Yan2; Xia, Lei2; Shen, Chengyin2; Chu, Yannan2
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| 刊名 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 412 |
| 关键词 | Breath analysis Modified APPI QTOFMS |
| ISSN号 | 1618-2642 |
| DOI | 10.1007/s00216-020-02602-y |
| 通讯作者 | Huang, Chaoqun(cqhuang@aiofm.ac.cn) |
| 英文摘要 | Breath analysis is a promising method for metabolomics studies and clinical diagnosis, as it enables the observation of metabolites in a convenient and noninvasive way. In this work, an atmospheric pressure photoionization (APPI) source was modified for online analysis of exhaled breath by coupling with quadrupole time-of-flight mass spectrometry (QTOFMS). Three parameters, namely, the capillary voltage, the sampling flow and the curtain gas flow of the APPI source, were optimized. Five healthy volunteers, three males and two females, were enrolled to test the performance of modified APPI-QTOFMS by analyzing their exhaled breath. A total of 21 compounds were tentatively identified, and four metabolites, namely, dimethyl selenoxide, delta-valerolactam, hydroxymandelic acid and palmitic amide were detected in the exhaled breath for the first time. The result shows that modified APPI-QTOFMS can be used for the online study of exhaled breath. |
| WOS关键词 | VOLATILE ORGANIC-COMPOUNDS ; ELECTROSPRAY-IONIZATION ; HUMAN SALIVA ; PTR-MS ; AIR ; ACETONE ; OXIDATION ; MICROEXTRACTION ; QUANTIFICATION ; CONDENSATE |
| 资助项目 | National Natural Science Foundation of China[61671434] ; National Natural Science Foundation of China[21876176] ; Key Program of 13th Five-Year Plan CASHIPS[KP-2017-25] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000528432100001 |
| 出版者 | SPRINGER HEIDELBERG |
| 资助机构 | National Natural Science Foundation of China ; Key Program of 13th Five-Year Plan CASHIPS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103373]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Huang, Chaoqun |
| 作者单位 | 1.Zhejiang Inst Metrol, 300 Xiasha Rd, Hangzhou 310018, Zhejiang, Peoples R China 2.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wenzhao,Huang, Chaoqun,Zou, Xue,et al. Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2020,412. |
| APA | Zhou, Wenzhao.,Huang, Chaoqun.,Zou, Xue.,Lu, Yan.,Xia, Lei.,...&Chu, Yannan.(2020).Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,412. |
| MLA | Zhou, Wenzhao,et al."Modification of an atmospheric pressure photoionization source for online analysis of exhaled breath coupled with quadrupole time-of-flight mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 412(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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