Inhibition of basal cell carcinoma cells by cold atmospheric plasma-activated solution and differential gene expression analysis
文献类型：期刊论文
| 作者 | Yang, Xingyu3; Yang, Chunjun3; Wang, Liyun3; Cao, Zhicheng3; Wang, Yuan4 ; Cheng, Cheng1; Zhao, Guoping5; Zhao, Ye2
|
| 刊名 | INTERNATIONAL JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2020-05-01 |
| 卷号 | 56 |
| 关键词 | CAP PAS BCC ROS RNA-sequencing MAPK |
| ISSN号 | 1019-6439 |
| DOI | 10.3892/ijo.2020.5009 |
| 通讯作者 | Yang, Chunjun(yangchunjun9@163.com) |
| 英文摘要 | Basal cell carcinoma is a common skin tumor. Cold atmospheric plasma (CAP) has attracted increasing attention for its antitumor effects. The aim of the present study was to investigate the effects and related mechanisms of two CAP-activated solutions on the TE354T basal cell carcinoma and HaCat keratinocyte cell lines. Plasma-activated solution (PAS) was prepared by CAP irradiation of DMEM and PBS. TE354T cells were treated with PAS in vitro and the effect on cell viability was evaluated by an MTT assay. The apoptosis rate was detected by Annexin V/propidium iodide staining. Furthermore, western blotting and RNA-sequencing were performed. The present results demonstrated that PAS induced apoptotic signaling in basal cell carcinoma cells, and that this effect was associated with the activation of the MAPK signaling pathway. Therefore, the present study demonstrated that PAS may serve as a novel treatment for basal cell carcinoma. |
| WOS关键词 | HYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; CANCER-CELLS ; APOPTOSIS ; SELECTIVITY ; PATHWAYS ; MEDIA |
| 资助项目 | Foundation of The Second Affiliated Hospital of Anhui Medical University[2015hhjh04] ; National Natural Science Foundation of China[51777206] ; National Natural Science Foundation of China[31600680] ; National Natural Science Foundation of China[81673099] ; National Natural Science Foundation of China[31670860] ; National Natural Science Foundation of China[81602083] ; National Natural Science Foundation of China[31800702] ; Anhui Provincial Natural Science Foundation[1608085QH216] ; Anhui Provincial Natural Science Foundation[1708085MA13] ; Grants for Scientific Research of BSKY from Anhui Medical University[XJ201505] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000528823800019 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Foundation of The Second Affiliated Hospital of Anhui Medical University ; National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation ; Grants for Scientific Research of BSKY from Anhui Medical University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103389]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yang, Chunjun |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Plasma Phys, Hefei 230031, Anhui, Peoples R China 2.Anhui Med Univ, Teaching & Res Sect Nucl Med, Hefei 230032, Anhui, Peoples R China 3.Anhui Med Univ, Affiliated Hosp 2, Dept Dermatol, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China 4.Anhui Med Univ, Dept Orthpaed, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xingyu,Yang, Chunjun,Wang, Liyun,et al. Inhibition of basal cell carcinoma cells by cold atmospheric plasma-activated solution and differential gene expression analysis[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2020,56. |
| APA | Yang, Xingyu.,Yang, Chunjun.,Wang, Liyun.,Cao, Zhicheng.,Wang, Yuan.,...&Zhao, Ye.(2020).Inhibition of basal cell carcinoma cells by cold atmospheric plasma-activated solution and differential gene expression analysis.INTERNATIONAL JOURNAL OF ONCOLOGY,56. |
| MLA | Yang, Xingyu,et al."Inhibition of basal cell carcinoma cells by cold atmospheric plasma-activated solution and differential gene expression analysis".INTERNATIONAL JOURNAL OF ONCOLOGY 56(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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