Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice
文献类型：期刊论文
| 作者 | Zhang, Jia1,8; Wang, Weiyi2; Zhou, Yuan1; Yang, Jing1; Xu, Jingli3; Xu, Zhiyuan4,5,6; Xu, Beihua1; Yan, Li7; Cheng, Xiang-Dong4,5,6; Li, Minghua8 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2020-04-08 |
| 卷号 | 11 |
| ISSN号 | 1663-9812 |
| 关键词 | terphenyllin pancreatic cancer metastasis Bax Bcl-2 Puma |
| DOI | 10.3389/fphar.2020.00457 |
| 通讯作者 | Wang, Weiyi(wywang@tio.org.cn) ; Li, Minghua(1035448060@qq.com) ; Qin, Jiang-Jiang(jqin@zcmu.edu.cn) |
| 英文摘要 | Pancreatic cancer (PC) is an aggressive and fatal disease with high incidences of metastasis and recurrence. However, there are no effective treatment options for the majority of PC patients, especially for those with locally advanced tumors and metastatic diseases. Therefore, it is urgently needed to develop safe and effective anti-PC therapeutic agents. We have recently identified a novel marine-derived natural product terphenyllin with potent anti-PC activity. The present study was designed to investigate the efficacy and mechanisms of action of terphenyllin in several human PC cell lines and an orthotopic PC mouse model. The results showed that terphenyllin significantly inhibited the viability of all PC cell lines with minimal effects on a normal human pancreatic cell line (HPNE). We next demonstrated the effects of terphenyllin on colony formation, apoptosis, migration, and invasion in both Panc1 and HPAC cell lines in a concentration-dependent manner. Terphenyllin also suppressed the tumor growth and metastasis in the Panc1 orthotopic mouse model. We further showed the profound effects of terphenyllin on the expression of apoptosis-associated proteins, including Bax, Bad, Puma, Bim(L), Bcl-2, phos-Bcl-2 (Ser70), Bcl-xL, caspase 7, and PARP, which contributed to its anti-PC activity. In summary, terphenyllin suppressed the PC cell growth and metastasis in vitro and in vivo and may be developed as an anti-PC therapeutic agent in the future. |
| WOS关键词 | MDM2 INHIBITOR ; IN-VITRO ; CANCER ; THERAPY ; IDENTIFICATION ; SURVIVAL ; TARGET ; GEMCITABINE ; PACLITAXEL ; FOLFIRINOX |
| 资助项目 | National Natural Science Foundation of China[81903842] ; National Natural Science Foundation of China[81573953] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2020ZZ005] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2016ZZ012] ; Zhejiang Chinese Medical University[111100E014] ; Medical Science and Technology Project of Zhejiang Province[WKJ-ZJ-1728] ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province[2018ZY006] ; Science and Technology Projects of Zhejiang Province[2019C03049] ; Foundation of Third Institute of Oceanography SOA[2017001] ; Foundation of Third Institute of Oceanography SOA[2018021] ; Natural Science Foundation of Fujian Province[2018J01064] ; COMRA program[DY135-B2-05] ; COMRA program[DY135-B2-01] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000529501700001 |
| 资助机构 | National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan ; Zhejiang Chinese Medical University ; Medical Science and Technology Project of Zhejiang Province ; Traditional Chinese Medical Science and Technology Major Project of Zhejiang Province ; Science and Technology Projects of Zhejiang Province ; Foundation of Third Institute of Oceanography SOA ; Natural Science Foundation of Fujian Province ; COMRA program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103431]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Weiyi; Li, Minghua; Qin, Jiang-Jiang |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China 2.Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China 5.Zhejiang Canc Hosp, Hangzhou, Peoples R China 6.Univ Chinese Acad Sci, Canc Hosp, Hangzhou, Peoples R China 7.Naval Med Univ, Sch Pharm, Shanghai, Peoples R China 8.Shanxi Prov Acad Tradit Chinese Med, Taiyuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jia,Wang, Weiyi,Zhou, Yuan,et al. Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice[J]. FRONTIERS IN PHARMACOLOGY,2020,11. |
| APA | Zhang, Jia.,Wang, Weiyi.,Zhou, Yuan.,Yang, Jing.,Xu, Jingli.,...&Qin, Jiang-Jiang.(2020).Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice.FRONTIERS IN PHARMACOLOGY,11. |
| MLA | Zhang, Jia,et al."Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice".FRONTIERS IN PHARMACOLOGY 11(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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