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Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells

文献类型：期刊论文

作者Yang, Xiaorui3,4; Chen, Guodong3; Yu, Kwan Ngok5,6; Yang, Miaomiao1,3,4; Peng, Shengjie3,4; Ma, Jie3; Qin, Feng3,4; Cao, Wei3,4; Cui, Shujun3,4; Nie, Lili3
刊名CELL DEATH & DISEASE
出版日期2020-04-27
卷号11
ISSN号2041-4889
DOI10.1038/s41419-020-2459-3
通讯作者Han, Wei(hanw@hfcas.ac.cn)
英文摘要Cold atmospheric plasma (CAP) has been proposed as a novel promising anti-cancer treatment modality. Apoptosis and necrosis have been revealed in CAP-induced cell death, but whether CAP induces pyroptosis, another kind of programmed cell death is still unknown. In the present study, we first reported that CAP effectively induced pyroptosis in a dose-dependent manner in Gasdermin E (GSDME) high-expressed tumor cell lines. Interestingly, the basal level of GSDME protein was positively correlated with the sensitivity to CAP in three selected cancer cell lines, implying GSDME might be a potential biomarker of prognosis in the forthcoming cancer CAP treatment. Moreover, our study revealed that CAP-induced pyroptosis depended on the activation of mitochondrial pathways (JNK/cytochrome c/caspase-9/caspase-3) and the cleavage of GSDME but not Gasdermin D (GSDMD). ROS generation induced by CAP was identified to initiate the pyroptotic signaling. These results complemented our knowledge on CAP-induced cell death and provide a strategy to optimize the effect of CAP cancer treatment.
WOS关键词NONTHERMAL PLASMA ; HEARING-LOSS ; DFNA5 GENE ; CANCER ; APOPTOSIS ; CISPLATIN ; CASPASE-3 ; CLEAVAGE
资助项目National Key R&D Program of China[2019YFC 0119000] ; Chinese National Natural Science Foundation[U1632145] ; Chinese National Natural Science Foundation[81227902] ; Chinese National Natural Science Foundation[81703168] ; Natural Science Fund of Anhui Province[1608085QH181] ; CASHIPS Director's Fund[YZJJ2018QN19] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong[IRF/0024]
WOS研究方向Cell Biology
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000530485500009
资助机构National Key R&D Program of China ; Chinese National Natural Science Foundation ; Natural Science Fund of Anhui Province ; CASHIPS Director's Fund ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103435]  
专题中国科学院合肥物质科学研究院
通讯作者Han, Wei
作者单位1.Anhui Med Univ, Clin pathol Ctr, Affiliated Hosp 4, Hefei, Anhui, Peoples R China
2.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou, Jiangsu, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei, Anhui, Peoples R China
4.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
5.City Univ Hong Kong, Dept Phys, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China
6.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China
7.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Xiaorui,Chen, Guodong,Yu, Kwan Ngok,et al. Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells[J]. CELL DEATH & DISEASE,2020,11.
APA Yang, Xiaorui.,Chen, Guodong.,Yu, Kwan Ngok.,Yang, Miaomiao.,Peng, Shengjie.,...&Han, Wei.(2020).Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells.CELL DEATH & DISEASE,11.
MLA Yang, Xiaorui,et al."Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells".CELL DEATH & DISEASE 11(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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