Biological roles of LSD1 beyond its demethylase activity
文献类型：期刊论文
| 作者 | Gu, Feiying3,4,5; Lin, Yuxin1; Wang, Zhun3,4,5; Wu, Xiaoxin6; Ye, Zhenyue2; Wang, Yuezhen3,4,5; Lan, Huiyin3,4,5 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2020-03-19 |
| 关键词 | LSD1 Demethylase Ubiquitylation FBXW7 Non-catalytic |
| ISSN号 | 1420-682X |
| DOI | 10.1007/s00018-020-03489-9 |
| 通讯作者 | Wang, Yuezhen(wangyz@zjcc.org.cn) ; Lan, Huiyin(lanhuiyin@zju.edu.cn) |
| 英文摘要 | It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A) roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for regulating gene expression. Though the discovery of non-histone substrates methylated by LSD1 has largely expanded the functions of LSD1 as a typical demethylase, recent groundbreaking studies unveiled its non-catalytic functions as a second life for this demethylase. We and others found that LSD1 is implicated in the interaction with a line of proteins to exhibit additional non-canonical functions in a demethylase-independent manner. Here, we present an integrated overview of these recent literatures charging LSD1 with unforeseen functions to re-evaluate and summarize its non-catalytic biological roles beyond the current understanding of its demethylase activity. Given LSD1 is reported to be ubiquitously overexpressed in a variety of tumors, it has been generally considered as an innovative target for cancer therapy. We anticipate that these non-canonical functions of LSD1 will arouse the consideration that extending the LSD1-based drug discovery to targeting LSD1 protein interactions non-catalytically, not only its demethylase activity, may be a novel strategy for cancer prevention. |
| WOS关键词 | HISTONE LYSINE DEMETHYLASES ; MESENCHYMAL TRANSITION ; EPIGENETIC REGULATION ; ESTROGEN-RECEPTOR ; CRYSTAL-STRUCTURE ; PROSTATE-CANCER ; DIFFERENTIATION ; KDM1A ; TRANSCRIPTION ; METHYLATION |
| 资助项目 | Natural Science Foundation of Zhejiang Province[20160171] ; Ningbo Natural Science Foundation, China[2016A610148] ; Medical Scientific Research Foundation of Zhejiang Province, China[2018KY689] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000521033900002 |
| 出版者 | SPRINGER BASEL AG |
| 资助机构 | Natural Science Foundation of Zhejiang Province ; Ningbo Natural Science Foundation, China ; Medical Scientific Research Foundation of Zhejiang Province, China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103467]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Yuezhen; Lan, Huiyin |
| 作者单位 | 1.Hosp Chinese Med Changxing Cty, Dept Oncol, Huzhou 313100, Peoples R China 2.Univ Chinese Acad Sci, Hwa Mei Hosp, Dept Resp Dis, Ningbo, Peoples R China 3.Chinese Acad Sci, ICBM, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 5.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 6.Zhejiang Univ, Natl Clin Res Ctr Infect Dis, State Key Lab Diag & Treatment Infect Dis, Sch Med,Affiliated Hosp 1, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Feiying,Lin, Yuxin,Wang, Zhun,et al. Biological roles of LSD1 beyond its demethylase activity[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2020. |
| APA | Gu, Feiying.,Lin, Yuxin.,Wang, Zhun.,Wu, Xiaoxin.,Ye, Zhenyue.,...&Lan, Huiyin.(2020).Biological roles of LSD1 beyond its demethylase activity.CELLULAR AND MOLECULAR LIFE SCIENCES. |
| MLA | Gu, Feiying,et al."Biological roles of LSD1 beyond its demethylase activity".CELLULAR AND MOLECULAR LIFE SCIENCES (2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。