Strong static magnetic field delayed the early development of zebrafish
文献类型：期刊论文
| 作者 | Ge, Shuchao2; Li, Jingchen1; Huang, Dengfeng2; Cai, Yuan2; Fang, Jun3 ; Jiang, Hongyuan1; Hu, Bing2
|
| 刊名 | OPEN BIOLOGY
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 9 |
| 关键词 | zebrafish early development strong static magnetic field microtubules spindle mitosis |
| DOI | 10.1098/rsob.190137 |
| 通讯作者 | Jiang, Hongyuan(jianghy@ustc.edu.cn) ; Hu, Bing(bhu@ustc.edu.cn) |
| 英文摘要 | One of the major topics in magnetobiology is the biological effects of strong static magnetic field (SMF) on living organisms. However, there has been a paucity of the comprehensive study of the long-term effects of strong SMF on an animal's development. Here, we explored this question with zebrafish, an excellent model organism for developmental study. In our research, zebrafish eggs, just after fertilization, were exposed to a 9.0 T SMF for 24 h, the critical period of post-fertilization development from cleavage to segmentation. The effects of strong SMF exposure on the following developmental progress of zebrafish were studied until 6 days post-fertilization (dpf). Results showed that 9.0 T SMF exposure did not influence the survival or the general developmental scenario of zebrafish embryos. However, it slowed down the developmental pace of the whole animal, and the late developers would catch up with their control peers after the SMF was removed. We proposed a mechanical model and deduced that the development delaying effect was caused by the interference of SMF in microtubule and spindle positioning during mitosis, especially in early cleavages. Our research data provide insights into how strong SMF influences the developing organisms through basic physical interactions with intracellular macromolecules. |
| WOS关键词 | EMBRYONIC-DEVELOPMENT ; XENOPUS-LAEVIS ; UPPER LIMIT ; SPINDLE ; MICROTUBULES ; ORIENTATION ; MECHANISMS ; ACTIN ; FORCE ; CELLS |
| 资助项目 | Chinese MOST[2019YFA0405600] ; NSFC[U1332136] ; NSFC[81790643] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | ROYAL SOC |
| WOS记录号 | WOS:000521587300004 |
| 资助机构 | Chinese MOST ; NSFC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103501]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Jiang, Hongyuan; Hu, Bing |
| 作者单位 | 1.Univ Sci & Technol China, CAS Ctr Excellence Complex Syst Mech, Dept Modern Mech, Hefei Natl Lab Phys Sci Microscale,CAS Key Lab Me, Hefei 230027, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China 3.Chinese Acad Sci, High Field Magnet Lab, Anhui Prov Key Lab Condensed Matter Phys Extreme, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Shuchao,Li, Jingchen,Huang, Dengfeng,et al. Strong static magnetic field delayed the early development of zebrafish[J]. OPEN BIOLOGY,2019,9. |
| APA | Ge, Shuchao.,Li, Jingchen.,Huang, Dengfeng.,Cai, Yuan.,Fang, Jun.,...&Hu, Bing.(2019).Strong static magnetic field delayed the early development of zebrafish.OPEN BIOLOGY,9. |
| MLA | Ge, Shuchao,et al."Strong static magnetic field delayed the early development of zebrafish".OPEN BIOLOGY 9(2019). |
入库方式： OAI收割
来源：合肥物质科学研究院
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